SCHEMBL3737385

SCHEMBL3737385

Clc1cc(Nc2cc(Cl)c(-c3c(Cl)c(Cl)c(Cl)c(Cl)c3Cl)c(Cl)c2)cc(Cl)c1-c1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 2/20 0.39
CYP3A4 P08684 2/20 0.36
ALDH1A1 P00352 3/20 0.35
AHR P35869 1/20 0.33
TSHR P16473 2/20 0.32
HSD17B10 Q99714 2/20 0.32
HPGD P15428 1/20 0.32
CASP1 P29466 1/20 0.32
RECQL P46063 1/20 0.32
SOS1 Q07889 1/20 0.32
TTR P02766 1/20 0.32
STK10 O94804 1/20 0.31
GSK3A P49840 1/20 0.31
GSK3B P49841 1/20 0.31
SLK Q9H2G2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1686399 0.77 RAPGEF4 (0.56) RAPGEF4CYP3A4ALDH1A1AHRTSHR
SCHEMBL4458192 0.77 ALDH1A1 (0.59) CYP3A4ALDH1A1AHRTSHRHSD17B10
SCHEMBL3729797 0.77 RAPGEF4 (0.30) RAPGEF4
SCHEMBL1902290 0.70 HSD17B10 (0.60) CYP3A4ALDH1A1TSHRHSD17B10HPGD
SCHEMBL4448782 0.69 CYP3A4 (0.69) CYP3A4ALDH1A1AHRTSHRHSD17B10
SCHEMBL3738920 0.69 RAPGEF4 (0.35) RAPGEF4CYP3A4AHR
SCHEMBL1686395 0.67 TSHR (0.57) RAPGEF4CYP3A4ALDH1A1TSHR
SCHEMBL4448471 0.67 CYP3A4 (0.67) CYP3A4ALDH1A1AHRTSHRHSD17B10
SCHEMBL24174904 0.65 HSD17B10 (0.57) RAPGEF4CYP3A4ALDH1A1TSHRHSD17B10
SCHEMBL630082 0.65 ALDH1A1 (0.44) CYP3A4ALDH1A1AHRTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100280197-A1 MODIFIED PARTICLE, SUPPORT, CATALYST COMPONENT FOR ADDITION POLYMERIZATION, CATALYST FOR ADDITION POLYMERIZATION, AND PROCESS FOR PRODUCING ADDITION POLYMER TAKAOKI KAZUO 2010-11-04 US disclosed
US-20030069127-A1 Modified particle,support, catalyst component for addition polymerization, catalyst for addition polymerization, and process for producing addition polymer SUMITOMO CHEMICAL COMPANY, LIMTED (JP) 2003-04-10 US disclosed
EP-1275662-A1 MODIFIED PARTICLE, SUPPORT, CATALYST COMPONENT FOR ADDITION POLYMERIZATION, CATALYST FOR ADDITION POLYMERIZATION, AND PROCESS FOR PRODUCING ADDITION POLYMER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-01-15 EP disclosed