Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10946077 | 1.00 | CYP19A1 (0.44) | CYP19A1CYP17A1MEN1KMT2ATDP1 | |
| SCHEMBL10886101 | 1.00 | CYP19A1 (0.44) | CYP19A1CYP17A1MEN1KMT2ATDP1 | |
| Potassium Ion SCHEMBL10886690 | 0.90 | TDP1 (0.52) | CYP19A1CYP17A1MEN1KMT2ATDP1 | |
| Potassium Ion SCHEMBL10886695 | 0.90 | TDP1 (0.52) | CYP19A1CYP17A1MEN1KMT2ATDP1 | |
| SCHEMBL10884295 | 0.90 | TDP1 (0.50) | CYP19A1CYP17A1MEN1KMT2ATDP1 | |
| Potassium Ion SCHEMBL10943952 | 0.90 | TDP1 (0.52) | CYP19A1CYP17A1MEN1KMT2ATDP1 | |
| SCHEMBL6707070 | 0.82 | PGR (0.57) | CYP19A1MEN1KMT2ATDP1NR3C1 | |
| SCHEMBL6707066 | 0.82 | PGR (0.57) | CYP19A1MEN1KMT2ATDP1NR3C1 | |
| SCHEMBL10885331 | 0.79 | LMNA (0.47) | CYP19A1MEN1KMT2ATDP1NR3C1 | |
| SCHEMBL10885323 | 0.79 | LMNA (0.47) | CYP19A1MEN1KMT2ATDP1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023639-A1 | Methods of Treatment | IMPERIAL INNOVATIONS LIMITED (GB) | 2009-01-22 | — | — | US | claimed |
| US-7417038-B1 | Methods of treating cachexia | IMPERIAL INNOVATIONS LIMITED (GB) | 2008-08-26 | — | — | US | claimed |
| US-7829596-B2 | Methods of treatment | IMPERIAL INNOVATIONS LIMITED (GB) | 2010-11-09 | — | — | US | disclosed |
| US-20090023639-A1 | Methods of Treatment | IMPERIAL INNOVATIONS LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
| US-7417038-B1 | Methods of treating cachexia | IMPERIAL INNOVATIONS LIMITED (GB) | 2008-08-26 | — | — | US | disclosed |