Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | IL6 | P05231 | 1/20 | 0.44 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | GLUL | P15104 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10885323 | 1.00 | LMNA (0.47) | LMNAMAPTCYP19A1HSD17B10NR3C1 | |
| SCHEMBL10946076 | 0.82 | SHBG (0.46) | LMNAMAPTCYP19A1HSD17B10NR3C1 | |
| SCHEMBL10883611 | 0.82 | SHBG (0.46) | LMNAMAPTCYP19A1HSD17B10NR3C1 | |
| SCHEMBL10886101 | 0.79 | CYP19A1 (0.44) | LMNAMAPTCYP19A1NR3C1PGR | |
| SCHEMBL10946077 | 0.79 | CYP19A1 (0.44) | LMNAMAPTCYP19A1NR3C1PGR | |
| SCHEMBL3737458 | 0.79 | CYP19A1 (0.44) | LMNAMAPTCYP19A1NR3C1PGR | |
| SCHEMBL10885058 | 0.79 | NR3C1 (0.38) | CYP19A1HSD17B10NR3C1PGRHIF1A | |
| SCHEMBL10885823 | 0.76 | CYP19A1 (0.35) | LMNAMAPTCYP19A1HSD17B10NR3C1 | |
| Potassium Ion SCHEMBL10882830 | 0.73 | LMNA (0.54) | LMNAMAPTCYP19A1HSD17B10NR3C1 | |
| Potassium Ion SCHEMBL10882834 | 0.73 | LMNA (0.54) | LMNAMAPTCYP19A1HSD17B10NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4502989-A | HYPOTENSIVE, ANTIEDEMIC | SHIONOGI & CO., LTD. (JP) | 1985-03-05 | — | — | US | claimed |
| EP-0115273-B1 | ALDOSTERONE-ANTAGONISTIC STEROIDS | SHIONOGI & CO., LTD. (JP) | 1986-11-20 | — | — | EP | disclosed |
| US-4502989-A | HYPOTENSIVE, ANTIEDEMIC | SHIONOGI & CO., LTD. (JP) | 1985-03-05 | — | — | US | disclosed |
| EP-0115273-A2 | Aldosterone-antagonistic steroids | SHIONOGI & CO., LTD. (JP) | 1984-08-08 | — | — | EP | disclosed |