Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8435546 | 0.87 | ALOX15 (0.55) | ELANEALOX15ESR1HIF1AKMT2A | |
| SCHEMBL10580118 | 0.85 | KMT2A (0.53) | ALOX15KMT2AKDM4ERECQLMEN1 | |
| SCHEMBL30431383 | 0.80 | KDM4E (0.36) | KMT2AKDM4ERECQLACHEMEN1 | |
| SCHEMBL30883175 | 0.80 | MAPT (0.57) | ELANEALOX15KMT2AKDM4EMEN1 | |
| SCHEMBL361508 | 0.80 | GAA (0.50) | ELANEALOX15ESR1HIF1AKMT2A | |
| SCHEMBL362210 | 0.80 | MAPT (0.57) | ELANEALOX15KMT2AKDM4EMEN1 | |
| SCHEMBL29176170 | 0.80 | MAPT (0.38) | KMT2AKDM4ERECQLMEN1SMN1; SMN2 | |
| SCHEMBL7927502 | 0.80 | ELANE (0.47) | ELANEALOX15ESR1HIF1AKMT2A | |
| SCHEMBL5404741 | 0.80 | TDP1 (0.57) | ELANEALOX15ESR1HIF1AKMT2A | |
| SCHEMBL8692787 | 0.80 | PTGS2 (0.53) | ELANEALOX15ESR1HIF1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100280113-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2010-11-04 | — | — | US | claimed |
| US-4826888-A | STORAGE STABLE, DISCOLORATION INHIBITION | MITSUBISHI RAYON CO., LTD. (JP) | 1989-05-02 | — | — | US | claimed |
| EP-0395251-A1 | Herbicidal sulfonamides | ICI AUSTRALIA LIMITED (AU) | 1990-10-31 | — | — | EP | disclosed |