Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.50 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BRS3 | P32247 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624401 | 0.98 | PIK3CD (0.52) | PIK3CDCOMTCHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL3743515 | 0.96 | PIK3CD (0.50) | PIK3CDCOMTCHRM2CHRM4CHRM5 | |
| SCHEMBL12763759 | 0.86 | PIK3CD (0.55) | PIK3CDCOMTPTGS1LMNATOP2A | |
| SCHEMBL3740023 | 0.84 | PIK3CD (0.41) | PIK3CDCOMTNPC1RAB9ACYP2D6 | |
| Bromide SCHEMBL3733597 | 0.78 | CYP2D6 (0.38) | PIK3CDCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL7384490 | 0.77 | OPRM1 (0.39) | PIK3CDCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL64615 | 0.75 | — | — | |
| Bromide SCHEMBL3731954 | 0.75 | PIK3CD (0.47) | PIK3CDCOMTNPC1RAB9AL3MBTL1 | |
| Bromide SCHEMBL3733694 | 0.74 | ALDH1A1 (0.41) | L3MBTL1 | |
| Hydrochloric Acid SCHEMBL2928953 | 0.74 | CYP2D6 (0.38) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900393-B1 | Hydrogen peroxide activation with diones and imidazoles | HENKEL AG & CO KGAA (DE) | 2018-02-28 | — | — | EP | disclosed |
| EP-1862198-B1 | Brightening and/or dyeing agent with urea derivatives | HENKEL AG & CO KGAA (DE) | 2017-04-05 | — | — | EP | disclosed |
| EP-2026754-B1 | LIGHTENING AND/OR COLOURING AGENT COMPRISING CYCLIC UREA DERIVATIVES | HENKEL AG & CO KGAA (DE) | 2015-09-30 | — | — | EP | disclosed |
| EP-2012742-B1 | BLEACHING AND/OR COLOURING AGENTS CONTAINING PIPERIDONES | HENKEL AG & CO KGAA (DE) | 2014-03-19 | — | — | EP | disclosed |
| US-20100278767-A1 | Lightening Agents and/or Dyes that Contain Aldehyde(s) | HENKEL AG & CO. KGAA (DE) | 2010-11-04 | — | — | US | disclosed |
| EP-2051689-A1 | LIGHTENING AGENTS AND/OR DYES THAT CONTAIN ALDEHYDE(S) | Henkel AG & Co. KGaA (DE) | 2009-04-29 | — | — | EP | disclosed |
| EP-2026754-A2 | LIGHTENING AND/OR COLOURING AGENT COMPRISING CYCLIC UREA DERIVATIVES | Henkel AG & Co. KGaA (DE) | 2009-02-25 | — | — | EP | disclosed |
| EP-2012742-A1 | BLEACHING AND/OR COLOURING AGENTS CONTAINING PIPERIDONES | Henkel AG & Co. KGaA (DE) | 2009-01-14 | — | — | EP | disclosed |
| EP-2007343-A1 | BLEACHING AGENTS CONTAINING PIPERIDONES | Henkel AG & Co. KGaA (DE) | 2008-12-31 | — | — | EP | disclosed |
| WO-2008068140-A2 | MEANS FOR BRIGHTENING COLOR MODIFICATION OF KERATINIC FIBERS, CONTAINING AN ALKYL PHOSPHORIC ACID ESTER | HENKEL AG & CO. KGAA (DE) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008022996-A1 | LIGHTENING AGENTS AND/OR COLORANTS CONTAINING POLYOL ESTERS | HENKEL AG & CO. KGAA (DE) | 2008-02-28 | — | — | WO | disclosed |
| EP-1892013-A2 | Hydrogen peroxide activation with nonionic compounds | Henkel Kommanditgesellschaft auf Aktien (DE) | 2008-02-27 | — | — | EP | disclosed |
| EP-1891927-A2 | Hydrogen peroxide activation with methanol (hetero)aromatic compounds | Henkel Kommanditgesellschaft auf Aktien (DE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2008019986-A1 | LIGHTENING AGENTS AND/OR DYES THAT CONTAIN ALDEHYDE(S) | HENKEL AG & CO. KGAA (DE) | 2008-02-21 | — | — | WO | disclosed |
| EP-1882495-A2 | Hydrogen peroxide activation with anionic tensides | Henkel Kommanditgesellschaft auf Aktien (DE) | 2008-01-30 | — | — | EP | disclosed |
| EP-1882470-A2 | Hydrogen peroxide activation with betaines and/or aminoxides | Henkel Kommanditgesellschaft auf Aktien (DE) | 2008-01-30 | — | — | EP | disclosed |
| WO-2007137676-A2 | LIGHTENING AND/OR COLOURING AGENT COMPRISING CYCLIC UREA DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2007-12-06 | — | — | WO | disclosed |
| EP-1862198-A2 | Brightening and/or dyeing agent with urea derivatives | Henkel Kommanditgesellschaft auf Aktien (DE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2007118618-A1 | BLEACHING AGENTS CONTAINING PIPERIDONES | HENKEL AG & CO. KGAA (DE) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007118617-A1 | BLEACHING AND/OR COLOURING AGENTS CONTAINING PIPERIDONES | HENKEL AG & CO. KGAA (DE) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100278767-A1 | Lightening Agents and/or Dyes that Contain Aldehyde(s) | CCR3, CBR3, CCRL2 | CHRM2 624/4885CHRM3 161/4885PIK3CD 4853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.