Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743089 | 1.00 | CCR2 (0.47) | CCR2HSD11B1CNR2OPRM1OPRD1 | |
| SCHEMBL744360 | 1.00 | CCR2 (0.47) | CCR2HSD11B1CNR2OPRM1OPRD1 | |
| SCHEMBL742585 | 0.76 | CCR2 (0.59) | CCR2CNR2OPRM1OPRD1OPRK1 | |
| SCHEMBL742587 | 0.76 | CCR2 (0.59) | CCR2CNR2OPRM1OPRD1OPRK1 | |
| SCHEMBL5235112 | 0.76 | CCR2 (0.59) | CCR2CNR2OPRM1OPRD1OPRK1 | |
| SCHEMBL742586 | 0.76 | CCR2 (0.59) | CCR2CNR2OPRM1OPRD1OPRK1 | |
| SCHEMBL744833 | 0.75 | CCR2 (0.47) | CCR2KCNH2MCHR1 | |
| SCHEMBL1307534 | 0.75 | CCR5 (0.35) | HRH3CCR5KCNH2MCHR1 | |
| SCHEMBL744081 | 0.75 | CCR2 (0.47) | CCR2HSD11B1CNR2OPRM1OPRD1 | |
| SCHEMBL3650966 | 0.75 | CCR2 (0.47) | CCR2HSD11B1CNR2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834021-B2 | 3-aminopyrrolidine derivatives as modulators of chemokine receptors | INCYTE CORPORATION (US) | 2010-11-16 | — | — | US | disclosed |
| US-20060252751-A1 | 3-Aminopyrrolidine derivaties as modulators of chemokine receptors | INCYTE HOLDINGS CORPORATION | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252751-A1 | 3-Aminopyrrolidine derivaties as modulators of chemokine receptors | CCR2, CXCR3, CCR5 | CCR2 1/4885HSD11B1 3098/4885CNR2 76/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.