Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | KCNA5 | P22460 | 8/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750327 | 0.90 | KMT2A (0.65) | TDP1KMT2AKCNA5SCN9ASCN5A | |
| SCHEMBL3745594 | 0.85 | SCN9A (0.46) | TDP1KMT2AKCNA5SCN9ASCN5A | |
| SCHEMBL3745776 | 0.82 | KCNA5 (0.62) | TDP1KMT2AKCNA5TSHRCYP3A4 | |
| SCHEMBL3752914 | 0.82 | TSHR (0.50) | TDP1KMT2AKCNA5SCN9ASCN5A | |
| SCHEMBL3758062 | 0.81 | TDP1 (0.79) | TDP1KMT2AKCNA5SCN9ASCN5A | |
| SCHEMBL3748598 | 0.80 | TDP1 (0.62) | TDP1KMT2AKCNA5SCN9ASCN5A | |
| SCHEMBL3754328 | 0.80 | KCNA5 (0.71) | KCNA5KCNH2 | |
| SCHEMBL3752979 | 0.80 | TSHR (0.49) | SCN9ASCN5ATSHRCYP3A4CYP2C9 | |
| SCHEMBL3761488 | 0.80 | KCNA5 (0.54) | KCNA5ALDH1A1KCNH2 | |
| SCHEMBL3746135 | 0.79 | ALDH1A1 (0.65) | KCNA5ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | claimed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | claimed |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015237-A1 | NEW COMPOUNDS I/418 | KCNH1, KCNH2, KCNH3 | TDP1 2095/4885KMT2A 3483/4885KCNA5 69/4885 |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | KCNH1, KCNH2, KCNQ2 | TDP1 1271/4885KMT2A 3979/4885KCNA5 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.