Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3744548 | 1.00 | LIPE (0.54) | LIPEALDH1A1POLBRAB9ALMNA | |
| SCHEMBL3742284 | 0.78 | BACE1 (0.66) | LIPEALDH1A1POLBRAB9ALMNA | |
| SCHEMBL3742285 | 0.78 | BACE1 (0.66) | LIPEALDH1A1POLBRAB9ALMNA | |
| SCHEMBL27842786 | 0.77 | RAB9A (0.67) | ALDH1A1POLBRAB9ALMNAKCNH2 | |
| SCHEMBL27888979 | 0.74 | KCNH2 (0.73) | LIPEALDH1A1POLBRAB9AKCNH2 | |
| SCHEMBL18390882 | 0.73 | KCNH2 (0.62) | ALDH1A1POLBRAB9ALMNAKCNH2 | |
| SCHEMBL18390868 | 0.73 | HRH3 (0.58) | ALDH1A1POLBRAB9ALMNAKCNH2 | |
| SCHEMBL18585930 | 0.71 | DRD2 (0.57) | ALDH1A1POLBRAB9ALMNANPC1 | |
| Hydrochloric Acid SCHEMBL27448507 | 0.71 | HRH3 (0.66) | LIPEALDH1A1POLBRAB9AKCNH2 | |
| SCHEMBL19493611 | 0.70 | RAB9A (0.62) | ALDH1A1POLBRAB9ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100280009-A1 | 3,4-SUBSTITUTED PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LLC | 2010-11-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280009-A1 | 3,4-SUBSTITUTED PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BACE1, BACE2, PSEN1 | LIPE 2809/4885ALDH1A1 1360/4885POLB 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.