SCHEMBL374556

SCHEMBL374556

O=C(O)c1cc(-c2cc(C(=O)O)c3ccccc3n2)nc2ccccc12.[NaH].[NaH]

nearest known ligand 0.96

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.80
LMNA P02545 2/20 0.80
SMN1; SMN2 Q16637 2/20 0.80
PDE10A Q9Y233 1/20 0.80
NPC1 O15118 1/20 0.78
RAB9A P51151 1/20 0.78
DHODH Q02127 4/20 0.75
MEN1 O00255 3/20 0.71
KMT2A Q03164 3/20 0.71
POLB P06746 3/20 0.71
ALDH1A1 P00352 2/20 0.67
GLA P06280 2/20 0.67
GAA P10253 2/20 0.67
AKR1C3 P42330 1/20 0.67
AKR1C2 P52895 1/20 0.67
AKR1C1 Q04828 1/20 0.67
ESR1 P03372 1/20 0.67
TP53 P04637 1/20 0.67
HPGD P15428 1/20 0.67
MAPK1 P28482 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18746 0.98 KDM4E (0.83) KDM4ELMNASMN1; SMN2PDE10ANPC1
SCHEMBL29359819 0.98 KDM4E (0.83) KDM4ELMNASMN1; SMN2PDE10ANPC1
Potassium SCHEMBL93448 0.96 KDM4E (0.80) KDM4ELMNASMN1; SMN2PDE10ANPC1
SCHEMBL30595092 0.96 KDM4E (0.80) KDM4ELMNASMN1; SMN2PDE10ANPC1
SCHEMBL374558 0.96 KDM4E (0.80) KDM4ELMNASMN1; SMN2PDE10ANPC1
SCHEMBL7962360 0.96 KDM4E (0.80) KDM4ELMNASMN1; SMN2PDE10ANPC1
SCHEMBL14518624 0.91 NPC1 (0.77) KDM4ELMNASMN1; SMN2PDE10ANPC1
SCHEMBL12131245 0.90 KDM4E (0.71) KDM4ELMNASMN1; SMN2PDE10ANPC1
Cinchophen SCHEMBL7588217 0.89 KDM4E (1.00) KDM4ELMNASMN1; SMN2PDE10ANPC1
Cinchophen SCHEMBL25519 0.89 KDM4E (1.00) KDM4ELMNASMN1; SMN2PDE10ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11739312-B2 Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them BASF ENZYMES LLC (US) 2023-08-29 US disclosed
US-20210198652-A1 Amylases and Glucoamylases, Nucleic Acids Encoding Them and Methods for Making and Using Them BASF ENZYMES LLC 2021-07-01 US disclosed
EP-3540053-B1 AMYLASES AND GLUCOAMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM BASF ENZYMES LLC (US) 2021-06-02 EP disclosed
US-10883098-B2 Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them BASF ENZYMES LLC (US) 2021-01-05 US disclosed
US-20200085070-A1 Amylases, Nucleic Acids Encoding Them and Methods for Making and Using Them BASF ENZYMES LLC 2020-03-19 US disclosed
EP-3540053-A1 AMYLASES AND GLUCOAMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM BASF Enzymes, LLC (US) 2019-09-18 EP disclosed
EP-3508578-A1 AMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM BASF Enzymes, LLC (US) 2019-07-10 EP disclosed
US-10329549-B2 Glucanases, nucleic acids encoding them and methods for making and using them BP CORPORATION NORTH AMERICA INC. (US) 2019-06-25 US disclosed
EP-3101128-B1 AMYLASES AND GLUCOAMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM BASF ENZYMES LLC (US) 2019-04-10 EP disclosed
US-20190032039-A1 Amylases and Glucoamylases, Nucleic Acids Encoding Them and Methods for Making and Using Them BASF ENZYMES LLC 2019-01-31 US disclosed
WO-2002055582-A2 MELT POLYCARBONATE CATALYST SYSTEMS GENERAL ELECTRIC COMPANY (US) 2002-07-18 WO disclosed
US-6303737-B1 POLYCONDENSATION CATALYSTS WHICH ARE SALTS OF CERTAIN PHENANTHROLINE COMPOUNDS; EXCELLENT POLYMERIZATION RATES; REDUCING THE LEVEL OF BRANCHING SIDE REACTION, I.E., FORMATION OF FRIES PRODUCT GENERAL ELECTRIC COMPANY 2001-10-16 US disclosed
US-6267961-B1 VACCINES; ACCURACY, UNIFORMITY BAXTER INTERNATIONAL INC. 2001-07-31 US disclosed
US-6187928-B1 TREATING FUNGAL DISEASES THE ROCKEFELLER UNIVERSITY 2001-02-13 US disclosed
US-6087510-A Method of use of imidazolium cations THE ROCKEFELLER UNIVERSITY (US) 2000-07-11 US disclosed
US-5969150-A FLUORESCENT COMPOUNDS FOR MEDICAL DIAGNOSIS, DRUGS AND LABELS OR FUNGICIDES AND VIRICIDES THE ROCKEFELLER UNIVERSITY (US) 1999-10-19 US disclosed
US-5874587-A FLUORESCENCE THE ROCKEFELLER UNIVERSITY (US) 1999-02-23 US disclosed
US-5790627-A Method and apparatus for observing a specimen using an X-ray microscope RESEARCH DEVELOPMENT CORP. (JP) 1998-08-04 US disclosed
EP-0763512-A1 AIR BAG GAS GENERATING AGENT OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1997-03-19 EP disclosed
US-5516700-A Automated urinalysis method CHIMERA RESEARCH AND CHEMICAL, INC. (US) 1996-05-14 US disclosed