Perflexane

Perflexane

SCHEMBL3745957

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[LiH]

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.57
THRB P10828 1/20 0.44
CA2 P00918 3/20 0.40
CA1 P00915 2/20 0.36
MMP1 P03956 2/20 0.36
MMP2 P08253 2/20 0.36
MMP9 P14780 2/20 0.36
MMP8 P22894 2/20 0.36
MMP13 P45452 2/20 0.36
F2 P00734 1/20 0.32
PRSS1 P07477 1/20 0.32
PRSS2 P07478 1/20 0.32
PRSS3 P35030 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4277216 1.00 LMNA (0.57) LMNATHRBCA2CA1MMP1
SCHEMBL9062775 1.00 LMNA (0.57) LMNATHRBCA2CA1MMP1
SCHEMBL1779065 0.94 LMNA (0.61) LMNATHRBCA2CA1MMP1
SCHEMBL1707474 0.94 LMNA (0.61) LMNATHRBCA2CA1MMP1
SCHEMBL1924377 0.94 LMNA (0.61) LMNATHRBCA2CA1MMP1
SCHEMBL771546 0.94 LMNA (0.61) LMNATHRBCA2CA1MMP1
Perflexane SCHEMBL3671912 0.94 LMNA (0.61) LMNATHRBCA2CA1MMP1
SCHEMBL984715 0.94 LMNA (0.61) LMNATHRBCA2CA1MMP1
Perflexane SCHEMBL20769778 0.94 LMNA (0.61) LMNATHRBCA2CA1MMP1
Perflexane SCHEMBL7507426 0.94 LMNA (0.61) LMNATHRBCA2CA1MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7846982-B2 Proton conducting electrolyte membrane having reduced methanol permeability and the use thereof in fuel cells PEMEAS GMBH (DE) 2010-12-07 US disclosed
US-7834131-B2 For polymer electrolyte membranes (PEM) fuel cells; polyazole film with smooth and rough side, doped with acid; e.g. polybenzimidazoles, polypyridobisimidazoles, polyareneazoles; good mechanical properties and an excellence proton conductivity; use with reformates from hydrocarbons BASF FUEL CELL GMBH (DE) 2010-11-16 US disclosed
US-20080026277-A1 For polymer electrolyte membranes (PEM) fuel cells; polyazole film with smooth and rough side, doped with acid; e.g. polybenzimidazoles, polypyridobisimidazoles, polyareneazoles; good mechanical properties and an excellence proton conductivity; use with reformates from hydrocarbons BASF FUEL CELL GMBH (DE) 2008-01-31 US disclosed
US-20050118477-A1 Proton conducting electrolyte membrane having reduced methanol permeability and the use thereof in fuel cells BASF FUEL CELL GMBH (DE) 2005-06-02 US disclosed