Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bethanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL11555700 | 0.83 | GRIN2B (0.56) | NPC1NOS2GRIN2BBLMLMNA | |
| Sulfuric Acid SCHEMBL11555704 | 0.83 | GRIN2B (0.56) | NPC1NOS2GRIN2BBLMLMNA | |
| Iodide SCHEMBL11379054 | 0.79 | NOS2 (0.50) | NPC1NOS2GRIN2BGAAGRIN1 | |
| Iodide SCHEMBL11379056 | 0.79 | NOS2 (0.50) | NPC1NOS2GRIN2BGAAGRIN1 | |
| Sulfuric Acid SCHEMBL4014387 | 0.76 | LMNA (0.65) | NOS2GRIN2BLMNAPMP22GRIN1 | |
| Bethanidine SCHEMBL122033 | 0.75 | KMT2A (0.43) | BLMLMNAPMP22KDM4EALDH1A1 | |
| Bethanidine SCHEMBL7530034 | 0.75 | KMT2A (0.43) | BLMLMNAPMP22KDM4EALDH1A1 | |
| Bethanidine SCHEMBL122035 | 0.75 | KMT2A (0.43) | BLMLMNAPMP22KDM4EALDH1A1 | |
| Bethanidine SCHEMBL29390473 | 0.75 | KMT2A (0.43) | BLMLMNAPMP22KDM4EALDH1A1 | |
| SCHEMBL14208801 | 0.75 | NOS2 (0.50) | NOS2GRIN2BGRIN1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023212790-A1 | COLLECTION ROOM FOR AMBULATORY EXAMS AND VACCINATION OF PEOPLE SUFFERING FROM AUTISM SPECTRUM DISORDER AND OTHER NEUROLOGICAL DISORDERS | NAIARA DE ASSIS CAMPOS MONALISA (BR) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023203083-A1 | METHODS AND KITS FOR PREDICTING LIVER-RELATED EVENTS IN PATIENTS SUFFERING FROM ALCOHOL-RELATED CIRRHOSIS | Institut National de la Santé et de la Recherche Médicale (FR) | 2023-10-26 | — | — | WO | disclosed |
| US-20230321201-A1 | PIC1 INHIBITION OF MYELOPEROXIDASE OXIDATIVE ACTIVITY IN AN ANIMAL MODEL | REALTA HOLDINGS, LLC (US) | 2023-10-12 | — | — | US | disclosed |
| US-11712462-B2 | PIC1 inhibition of myeloperoxidase oxidative activity in an animal model | REALTA HOLDINGS, LLC (US) | 2023-08-01 | — | — | US | disclosed |
| CN-115837050-A | Application of vesicle grass processed product | 内蒙古民族大学 | 2023-03-24 | — | — | CN | disclosed |
| US-11532888-B2 | Frequency reconfigurable monopolar wire-plate antenna | Commissariat à l'Energie Atomique et aux Energies Alternatives (FR) | 2022-12-20 | — | — | US | disclosed |
| CN-109342382-B | Preparation method of deacidification functional paper with pH response fluorescent probe | 复旦大学 | 2022-11-15 | — | — | CN | disclosed |
| US-11158947-B2 | Monopole wire-plate antenna | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2021-10-26 | — | — | US | disclosed |
| US-11135272-B2 | PIC1 inhibition of myeloperoxidase oxidative activity in an animal model | REALTA HOLDINGS, LLC (US) | 2021-10-05 | — | — | US | disclosed |
| US-20210288409-A1 | FREQUENCY RECONFIGURABLE MONOPOLAR WIRE-PLATE ANTENNA | Commissariat à l'Energie Atomique et aux Energies Alternatives (FR) | 2021-09-16 | — | — | US | disclosed |
| WO-1999063060-A1 | THE PRODUCTION OF PRIMMORPHS FROM DISASSOCIATED CELLS OF SPONGES, CORALS AND OTHER INVERTEBRATES, AND USE THEREOF | MUELLER WERNER E G (DE) | 1999-12-09 | — | — | WO | disclosed |
| US-5880076-A | PERSONAL PRODUCT OR DETERGENT COMPOSITION COMPRISING CYCLIC GLYCACARBAMATE AND/OR GLYCAUREA, SURFACTANT | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1999-03-09 | — | — | US | disclosed |
| EP-0649560-B1 | PROCESS FOR SELECTIVELY CONCENTRATING THE RADIOACTIVITY OF THORIUM CONTAINING MAGNESIUM SLAG | DOW CHEMICAL CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5537326-A | System for manufacturing parts for a functional device such as a cyclone | FISH RANDALL C (US) | 1996-07-16 | — | — | US | disclosed |
| US-5302670-A | Plastics on fatty acid basis | BATTELLE-INSTITUT E.V. (DE) | 1994-04-12 | — | — | US | disclosed |
| US-5094774-A | HIGH-FLOWABILITY AQUEOUS NICKEL HYDROXIDE OR HYDRATED NICKEL OXIDE PASTE FOR VIBRATION FILLING ELECTRODE FRAMEWORKS | DUETSCHE AUTOMOBILGESELLSCHAFT MBH (DE) | 1992-03-10 | — | — | US | disclosed |
| US-4798081-A | High temperature continuous viscometry coupled with analytic temperature rising elution fractionation for evaluating crystalline and semi-crystalline polymers | THE DOW CHEMICAL COMPANY (US) | 1989-01-17 | — | — | US | disclosed |
| US-4166234-A | FLUORESCENT DISCHARGE LAMP HAVING LUMINESCENT MATERIAL OF A SPECIFIED GRAIN SIZE | U.S. PHILIPS CORPORATION (US) | 1979-08-28 | — | — | US | disclosed |
| US-4069064-A | Phthalocyanine formulations having high gloss, which are stabilized against recrystallization and against change of modification | BASF AKTIENGESELLSCHAFT (DT) | 1978-01-17 | — | — | US | disclosed |
| US-3974320-A | Synthetic leather product and method of production | AKZO N.V. OF ARNHEM, HOLLAND (DT) | 1976-08-10 | — | — | US | disclosed |