Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13041228 | 1.00 | CYP1A2 (0.41) | CYP1A2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL15887301 | 0.81 | CYP2D6 (0.41) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL12567221 | 0.81 | CYP2D6 (0.42) | CYP1A2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9005331 | 0.78 | CYP2D6 (0.39) | CYP1A2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL28328046 | 0.78 | L3MBTL1 (0.38) | CYP1A2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL27643221 | 0.77 | CYP1A2 (0.55) | CYP1A2KMT2ANR1I2PGRADORA3 | |
| SCHEMBL27527957 | 0.77 | CYP1A2 (0.55) | CYP1A2KMT2APOLBNR1I2PGR | |
| SCHEMBL17524245 | 0.76 | CYP1A2 (0.47) | CYP1A2KMT2APOLBKDM4EDUSP3 | |
| SCHEMBL14520421 | 0.76 | CYP2D6 (0.40) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3601599 | 0.76 | CYP2D6 (0.40) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735609-B2 | Bryostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-8497385-B2 | Bryostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-07-30 | — | — | US | disclosed |
| US-20130123518-A1 | Bryostatin Analogues, Synthetic Methods and Uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-05-16 | — | — | US | disclosed |
| US-20100280262-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-11-04 | — | — | US | disclosed |
| US-20090270492-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2009-10-29 | — | — | US | disclosed |
| WO-2009052507-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2009-04-23 | — | — | WO | disclosed |
| US-20070270485-A1 | Byrostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2007-11-22 | — | — | US | disclosed |
| US-7256286-B2 | Bryostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-08-14 | — | — | US | disclosed |
| US-20030220334-A1 | Byrostatin analogues, synthetic methods and uses | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-11-27 | — | — | US | disclosed |
| WO-2003070719-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2003-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220334-A1 | Byrostatin analogues, synthetic methods and uses | BID, HASPIN, HPGDS | CYP1A2 3958/4885HDAC3 2788/4885HDAC1 2716/4885 |
| US-20090270492-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | PBK, TK1, BAK1 | CYP1A2 4088/4885HDAC3 420/4885HDAC1 159/4885 |
| US-20070270485-A1 | Byrostatin analogues, synthetic methods and uses | BID, HASPIN, HPGDS | CYP1A2 3958/4885HDAC3 2788/4885HDAC1 2716/4885 |
| US-20100280262-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | MCL1, PBK, BID | CYP1A2 4724/4885HDAC3 1328/4885HDAC1 824/4885 |
| US-20130123518-A1 | Bryostatin Analogues, Synthetic Methods and Uses | MCL1, PBK, BID | CYP1A2 4724/4885HDAC3 1328/4885HDAC1 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.