Sugi Predict

Sugi Predict / Compounds / SCHEMBL3748063

SCHEMBL3748063

SCHEMBL3748063

C=C(C)C(=O)ONC(=O)CC(=O)NOC(=O)C(=C)C

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.52
▸ TSHR P16473 3/20 0.41
▸ TDP1 Q9NUW8 2/20 0.39
▸ THRB P10828 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3749937 0.91 ALDH1A1 (0.48) ALDH1A1TSHRTDP1THRB
SCHEMBL6153042 0.91 ALDH1A1 (0.48) ALDH1A1TSHRTDP1THRB
SCHEMBL3754716 0.89 ALDH1A1 (0.46) ALDH1A1TSHRTDP1THRB
SCHEMBL3752235 0.89 ALDH1A1 (0.46) ALDH1A1TSHRTDP1THRB
SCHEMBL27826454 0.83 ALDH1A1 (0.41) ALDH1A1TSHRTDP1THRB
SCHEMBL22852547 0.83 ALDH1A1 (0.41) ALDH1A1TSHRTDP1THRB
SCHEMBL28718766 0.83 ALDH1A1 (0.41) ALDH1A1TSHRTDP1THRB
SCHEMBL14798778 0.83 PHF8 (0.43) ALDH1A1TSHRTHRB
SCHEMBL16376102 0.82 ALDH1A1 (0.55) ALDH1A1TSHRTDP1THRBHSD17B10
SCHEMBL1115358 0.82 ALDH1A1 (0.55) ALDH1A1TSHRTDP1THRBHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7838699-B2 Embolization using degradable crosslinked hydrogels BIOSPHERE MEDICAL (US) 2010-11-23 — — US disclosed
US-7135593-B2 Degradable crosslinkers, and degradable crosslinked hydrogels comprising them BIOSPHERE MEDICAL, INC. (US) 2006-11-14 — — US disclosed
US-20050113285-A1 Degradable crosslinkers, and degradable crosslinked hydrogels comprising them WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT 2005-05-26 — — US disclosed
US-6713646-B2 Degradable crosslinkers, and degradable crosslinked hydrogels comprising them BIOSPHERE MEDICAL 2004-03-30 — — US disclosed
US-20030215519-A1 Embolization using degradable crosslinked hydrogels WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT 2003-11-20 — — US disclosed
WO-2003094930-A1 EMBOLIZATION USING DEGRADABLE CROSSLINKED HYDROGELS BIOSPHERE MEDICAL, INC. (US) 2003-11-20 — — WO disclosed
WO-2003086316-A2 DEGRADABLE CROSSLINKERS, AND DEGRADABLE CROSSLINKED HYDROGELS COMPRISING THEM BIOSPHERE MEDICAL, INC. (US) 2003-10-23 — — WO disclosed
US-20030199654-A1 DEGRADABLE CROSSLINKERS, AND DEGRADABLE CROSSLINKED HYDROGELS COMPRISING THEM WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT 2003-10-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050113285-A1 Degradable crosslinkers, and degradable crosslinked hydrogels comprising them GFER, RAD52, ESD ALDH1A1 497/4885TSHR 2627/4885TDP1 483/4885
US-20030199654-A1 DEGRADABLE CROSSLINKERS, AND DEGRADABLE CROSSLINKED HYDROGELS COMPRISING THEM GFER, RAD52, ESD ALDH1A1 497/4885TSHR 2627/4885TDP1 483/4885
US-20030215519-A1 Embolization using degradable crosslinked hydrogels PLG, PLAU, FGB ALDH1A1 1040/4885TSHR 1876/4885TDP1 999/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.