ESD — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL27997401	1.00	1/20
SCHEMBL6292699	0.75	1/20
SCHEMBL27997620	0.65	1/20
SCHEMBL6294300	0.63	1/20
SCHEMBL27997398	0.61	1/20
SCHEMBL6298090	0.61	1/20
SCHEMBL6298319	0.60	1/20
SCHEMBL6298325	0.60	1/20
SCHEMBL6294160	0.58	1/20
SCHEMBL4942223	0.55	1/20
SCHEMBL22795865	0.55	1/20
SCHEMBL19866240	0.53	1/20
SCHEMBL10855110	0.53	1/20
SCHEMBL22796281	0.53	1/20
SCHEMBL7586677	0.53	1/20
SCHEMBL16740643	0.53	1/20
SCHEMBL6294124	0.52	1/20
SCHEMBL6293086	0.51	1/20
SCHEMBL16740653	0.50	1/20
SCHEMBL16740631	0.48	1/20

Clinical trials — most relevant to ESD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment	PHASE4	RECRUITING
Randomized Controlled Trial of Silymarin in Asthma	PHASE2/PHASE3	WITHDRAWN
Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine	PHASE2/PHASE3	UNKNOWN
Safety, Tolerability and Exploratory Efficacy of EC5026 in Parkinson's Disease (STEP Study)	PHASE1/PHASE2	RECRUITING
Safety, Tolerability, and Pharmacokinetics of Multiple Doses of Oral EC5026 in Healthy Subjects	PHASE1	COMPLETED
A Dose Escalation Trial of Radiation Therapy (RT) for Hepatocellular Carcinoma (HCC)	PHASE1	UNKNOWN
A Study to Assess the Transfer of Fospropofol and Its Active Metabolite, Propofol, to Breast Milk Following Administration of LUSEDRA to Lactating Women Undergoing a Needed Procedure	PHASE1	COMPLETED
GSNOR Phenotyping/GSNO Challenge in Severe Asthma	EARLY_PHASE1	COMPLETED
Genetic Variants and Regulation of Specialized Pro-resolving Mediator	nan	RECRUITING
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC	nan	COMPLETED
Prospective Collection of Endoscopic and Histopathologic Data from Endoscopic Procedures Performed in UZ Gent	nan	RECRUITING
Genetic and Environmental Risk Factors Related to Esophageal Cancer	nan	ACTIVE_NOT_RECRUITING
EDN and Eosinophilic Esophagitis	nan	RECRUITING
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer	nan	UNKNOWN
Impact of Hybrid-ESD+ and LiftUp® on the en Bloc/R0 Rate in Colorectal Adenomas Between 2 and 3 cm	nan	WITHDRAWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Expression of TET1 Gene in Acute Leukaemia	nan	UNKNOWN
Endoscopic Submucosal Dissection (ESD)	nan	RECRUITING
Effects of Green Tea Extract (GTE) on Systemic Oxidative and Antioxidative Status in Chinese Patients With Stable Asthma	nan	COMPLETED
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus	nan	ACTIVE_NOT_RECRUITING
Esophageal String Test in Eosinophilic Esophagitis	nan	ACTIVE_NOT_RECRUITING
Colorectal Omics and ofCS Proteoglycans (COCO) in Screening and a Diagnostic Pathway	nan	NOT_YET_RECRUITING
Exploration and Verification of DNA Methylolation in Early Screening of Esophageal Cancer	nan	UNKNOWN
Epigenome-wide DNA Methylation Profiling in Aneurysmal Subarachnoid Hemorrhage and Delayed Ischemic Neurologic Deficit	nan	ACTIVE_NOT_RECRUITING
Circumferential Submucosal Incision Endoscopic Mucosal Resection Versus Conventional Endoscopic Mucosal Resection of Colonic Polyps	nan	WITHDRAWN
Individualizing Anti-TNF Therapy in Patients With Inflammatory Bowel Disease	nan	RECRUITING
An Endoscopic Barbed-clips Suturing for Colorectal ESD	nan	UNKNOWN
Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage Function	nan	COMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits	nan	COMPLETED
Effect of Mepolizumab on Severe Eosinophilic Asthma	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ESD binder may also engage these)

Protein	Name	Similarity
Q9GJT2	—	1.000	Q9GJT2 →
Q08E20	—	1.000	Q08E20 →
B0BNE5	—	1.000	B0BNE5 →
Q9R0P3	—	0.998	Q9R0P3 →
Q8LAS8	—	0.993	Q8LAS8 →
A7ZNX7	—	0.993	A7ZNX7 →
B1J086	—	0.992	B1J086 →
B1IYB5	—	0.992	B1IYB5 →
A1A834	—	0.991	A1A834 →
P51025	—	0.991	P51025 →
P33018	—	0.991	P33018 →
Q3Z551	—	0.991	Q3Z551 →
Q8FFU3	—	0.991	Q8FFU3 →
Q0TKS8	—	0.990	Q0TKS8 →
Q1RFI8	—	0.990	Q1RFI8 →
Q8FKG2	—	0.990	Q8FKG2 →
Q8X635	—	0.990	Q8X635 →
A1AD14	—	0.990	A1AD14 →
Q8X5J5	—	0.989	Q8X5J5 →
Q1R9R8	—	0.989	Q1R9R8 →
Q31YW2	—	0.989	Q31YW2 →
B1LKQ1	—	0.989	B1LKQ1 →
Q0TFT6	—	0.988	Q0TFT6 →
B1X7P2	—	0.988	B1X7P2 →
A8A215	—	0.988	A8A215 →
A1AXZ2	—	0.988	A1AXZ2 →
Q3Z052	—	0.987	Q3Z052 →
Q0T2X0	—	0.987	Q0T2X0 →
A7ZX03	—	0.986	A7ZX03 →
B1XEU8	—	0.986	B1XEU8 →