Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1526184 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL17422 | 0.94 | CA4 (0.46) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL30145601 | 0.94 | — | — | |
| Bicarbonate SCHEMBL12500507 | 0.89 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL31265062 | 0.89 | — | — | |
| Bicarbonate SCHEMBL14333845 | 0.89 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL15401807 | 0.89 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL1491908 | 0.89 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL3446226 | 0.89 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL6541114 | 0.89 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902864-B2 | Two-coat barrier system comprising polyurethane | SUN CHEMICAL CORPORATION (US) | 2018-02-27 | — | — | US | disclosed |
| EP-2691432-B1 | A TWO-COAT BARRIER SYSTEM COMPRISING POLYURETHANE | SUN CHEMICAL BV (NL) | 2015-01-21 | — | — | EP | disclosed |
| US-20140212661-A1 | TWO-COAST BARRIER SYSTEM COMPRISING POLYURETHANE | SUN CHEMICAL CORPORATION (US) | 2014-07-31 | — | — | US | disclosed |
| US-8716402-B2 | Barrier coating comprising a polyurethane dispersion and elastomeric material | TEMPLE RODGER G (US) | 2014-05-06 | — | — | US | disclosed |
| EP-2691432-A2 | A TWO-COAT BARRIER SYSTEM COMPRISING POLYURETHANE | Sun Chemical B.V. (NL) | 2014-02-05 | — | — | EP | disclosed |
| WO-2012131362-A2 | A TWO-COAT BARRIER SYSTEM COMPRISING POLYURETHANE | SUN CHEMICAL B.V. (NL) | 2012-10-04 | — | — | WO | disclosed |
| US-20100174032-A1 | Barrier Coating Comprising a Polyurethane Dispersion and Elastomeric Material | PPG INDUSTRIES OHIO, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| WO-2005093000-A1 | BARRIER COATING COMPRISING A POLYURETHANE DISPERSION | PPG INDUSTRIES OHIO, INC. (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005093001-A1 | BARRIER COATING COMPRISING A POLYURETHANE DISPERSION AND ELASTOMERIC MATERIAL | PPG INDUSTRIES OHIO, INC. (US) | 2005-10-06 | — | — | WO | disclosed |
| US-20050196601-A1 | Microporous sheets with barrier coatings | PPG INDUSTRIES OHIO, INC. | 2005-09-08 | — | — | US | disclosed |
| US-20050197481-A1 | Barrier coating comprising a polyurethane dispersion | PPG INDUSTRIES OHIO, INC. | 2005-09-08 | — | — | US | disclosed |
| US-20050197480-A1 | Barrier coating comprising a polyurethane dispersion and elastomeric material | PPG INDUSTRIES OHIO, INC. | 2005-09-08 | — | — | US | disclosed |