Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 19/20 | 0.59 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.59 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.59 |
| ▸ | PSMD11 | O00231 | 2/20 | 0.59 |
| ▸ | PSMD12 | O00232 | 2/20 | 0.59 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.59 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.59 |
| ▸ | PSMD3 | O43242 | 2/20 | 0.59 |
| ▸ | PSMC3 | P17980 | 2/20 | 0.59 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.59 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.59 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.59 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.59 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.59 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.59 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.59 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.59 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.59 |
| ▸ | PSMC2 | P35998 | 2/20 | 0.59 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4343744 | 1.00 | PSMB5 (0.59) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL3746274 | 0.88 | PSMB5 (0.65) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| Hydrochloric Acid SCHEMBL3746894 | 0.86 | PSMB5 (0.61) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| Hydrochloric Acid SCHEMBL4339493 | 0.86 | PSMB5 (0.61) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL3753371 | 0.85 | PSMB5 (0.66) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL3759184 | 0.85 | PSMB5 (0.66) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL3740664 | 0.84 | PSMB5 (0.66) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20779065 | 0.84 | PSMB5 (0.67) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL20972368 | 0.84 | PSMB5 (0.67) | PSMB5PSMB1PSMB11PSMD11PSMD12 | |
| SCHEMBL2331686 | 0.84 | PSMB5 (0.67) | PSMB5PSMB1PSMB11PSMD11PSMD12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212334-B1 | PROTEASOME INHIBITORS | MILLENNIUM PHARM INC (US) | 2012-08-15 | — | — | EP | disclosed |
| US-7838673-B2 | Proteasome inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-11-23 | — | — | US | disclosed |
| US-20090099132-A1 | Proteasome inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099132-A1 | Proteasome inhibitors | PSMB5, PSMG3, PSMB1 | PSMB5 1/4885PSMB1 3/4885PSMB11 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.