Sugi Predict

Sugi Predict / Compounds / SCHEMBL3749131

SCHEMBL3749131

SCHEMBL3749131

NN=c1ccc2c(-c3ccccc3)c3ccc(NN)cc3oc-2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.46
▸ KMT2A Q03164 3/20 0.46
▸ USP2 O75604 3/20 0.46
▸ POLB P06746 2/20 0.46
▸ ATM Q13315 2/20 0.46
▸ PLEC Q15149 1/20 0.46
▸ THRB P10828 1/20 0.43
▸ RECQL P46063 1/20 0.43
▸ BLM P54132 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ TOP2A P11388 6/20 0.36
▸ ABCB1 P08183 1/20 0.34
▸ CFTR P13569 1/20 0.33
▸ PAX8 Q06710 1/20 0.33
▸ GOPC Q9HD26 1/20 0.33
▸ ALPL P05186 1/20 0.33
▸ ALPI P09923 1/20 0.33
▸ ALPG P10696 1/20 0.33
▸ F2 P00734 1/20 0.32
▸ F10 P00742 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19143845 0.84 KMT2A (0.49) MEN1KMT2AUSP2POLBATM
SCHEMBL3745356 0.83 MEN1 (0.47) MEN1KMT2AUSP2POLBATM
SCHEMBL3745354 0.83 MEN1 (0.47) MEN1KMT2AUSP2POLBATM
SCHEMBL13045840 0.82 ABCB1 (0.39) MEN1KMT2AUSP2POLBATM
SCHEMBL3744889 0.82 ABCB1 (0.39) MEN1KMT2AUSP2POLBATM
SCHEMBL3744887 0.82 ABCB1 (0.39) MEN1KMT2AUSP2POLBATM
SCHEMBL19849676 0.79 MEN1 (0.46) MEN1KMT2AUSP2POLBATM
SCHEMBL12982966 0.72 AR (0.41) MEN1KMT2AUSP2POLBATM
SCHEMBL23083077 0.71 MEN1 (0.46) MEN1KMT2AUSP2POLBATM
SCHEMBL17553574 0.70 LMNA (0.41) MEN1KMT2AUSP2POLBATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009094536-A1 FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS Life Technologies Corporation (US) 2009-07-30 — — WO claimed
US-10006918-B2 Fluorogenic hydrazine-substituted compounds Life Technologies Corporation (US) 2018-06-26 — — US disclosed
US-20160356782-A1 FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS Life Technologies Corporation 2016-12-08 — — US disclosed
US-9389183-B2 Fluorogenic hydrazine-substituted compounds Life Technologies Corporation (US) 2016-07-12 — — US disclosed
US-8772487-B2 Fluorogenic hydrazine-substituted compounds Life Technologies Corporation (US) 2014-07-08 — — US disclosed
US-20130288911-A1 FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS Life Technologies Corporation 2013-10-31 — — US disclosed
US-20100291547-A1 FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS Life Technologies Corporation (US) 2010-11-18 — — US disclosed
WO-2009094536-A1 FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS Life Technologies Corporation (US) 2009-07-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100291547-A1 FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS ALDH2, ALDH1A2, HLCS MEN1 2294/4885KMT2A 2025/4885USP2 3504/4885
US-10006918-B2 Fluorogenic hydrazine-substituted compounds ALDH2, ALDH1A2, HLCS MEN1 2294/4885KMT2A 2025/4885USP2 3504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.