Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30675321 | 0.83 | NPC1 (0.58) | KMT2ATDP1KDM4ENPC1RAB9A | |
| SCHEMBL30675320 | 0.79 | NPC1 (0.53) | KMT2ACA2TDP1KDM4ENPC1 | |
| SCHEMBL16736489 | 0.79 | NPC1 (0.53) | KMT2ATDP1KDM4ENPC1RAB9A | |
| SCHEMBL2098094 | 0.79 | NPC1 (0.53) | KMT2ACA2TDP1KDM4ENPC1 | |
| SCHEMBL15326460 | 0.76 | NPC1 (0.47) | KMT2ATDP1KDM4ENPC1RAB9A | |
| SCHEMBL31078939 | 0.75 | RAB9A (0.49) | KMT2ACA2TDP1KDM4ENPC1 | |
| SCHEMBL8517411 | 0.75 | IKBKB (0.55) | KMT2ATDP1KDM4ENPC1RAB9A | |
| SCHEMBL7780171 | 0.75 | KDM4E (0.55) | KMT2ACA2TDP1KDM4ENPC1 | |
| SCHEMBL27493245 | 0.73 | CA2 (0.56) | KMT2ACA2TDP1KDM4ENPC1 | |
| SCHEMBL2468542 | 0.72 | KMT2A (0.67) | KMT2ACA2TDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |