Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30675321 | 0.81 | NPC1 (0.58) | KDM4ETDP1NPC1RAB9AL3MBTL1 | |
| SCHEMBL7779177 | 0.80 | KDM4E (0.44) | KDM4ETDP1NPC1RAB9AL3MBTL1 | |
| SCHEMBL4160781 | 0.77 | ALDH1A1 (0.60) | KDM4ETDP1NPC1RAB9AL3MBTL1 | |
| SCHEMBL30675320 | 0.76 | NPC1 (0.53) | KDM4ETDP1NPC1RAB9AL3MBTL1 | |
| SCHEMBL16736489 | 0.76 | NPC1 (0.53) | KDM4ETDP1NPC1RAB9AL3MBTL1 | |
| SCHEMBL2098094 | 0.76 | NPC1 (0.53) | KDM4ETDP1NPC1RAB9AL3MBTL1 | |
| SCHEMBL31078939 | 0.76 | RAB9A (0.49) | KDM4ETDP1NPC1RAB9AL3MBTL1 | |
| SCHEMBL339492 | 0.75 | ALOX15 (0.81) | PTPN7ALOX15MEN1KMT2AALDH1A1 | |
| SCHEMBL22663 | 0.75 | CYP3A4 (0.59) | NPC1RAB9AL3MBTL1CA2ALDH1A1 | |
| SCHEMBL3750026 | 0.75 | KMT2A (0.60) | KDM4ETDP1NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135377-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034254-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | disclosed |