Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750194 | 1.00 | ALDH1A1 (0.35) | ALDH1A1KDM4EHSD17B10GAATSHR | |
| SCHEMBL3750191 | 1.00 | ALDH1A1 (0.35) | ALDH1A1KDM4EHSD17B10GAATSHR | |
| SCHEMBL3749861 | 0.89 | GAA (0.35) | ALDH1A1GAATET2SMN1; SMN2MAPT | |
| SCHEMBL3749863 | 0.89 | GAA (0.35) | ALDH1A1GAATET2SMN1; SMN2MAPT | |
| SCHEMBL3749866 | 0.89 | GAA (0.35) | ALDH1A1GAATET2SMN1; SMN2MAPT | |
| SCHEMBL1261183 | 0.86 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAASMN1; SMN2MAPT | |
| SCHEMBL1261184 | 0.86 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAASMN1; SMN2MAPT | |
| SCHEMBL3757293 | 0.82 | ALDH1A1 (0.34) | ALDH1A1KDM4EGAATET2SMN1; SMN2 | |
| SCHEMBL3757291 | 0.82 | ALDH1A1 (0.34) | ALDH1A1KDM4EGAATET2SMN1; SMN2 | |
| SCHEMBL3757297 | 0.82 | ALDH1A1 (0.34) | ALDH1A1KDM4EGAATET2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298311-A1 | TETRAHYDRONAPHTHALENE DERIVATES, PROCESS FOR PREPARING THEM AND THEIR USE AS ANTIINFLAMMATORY AGENTS | BERGER MARKUS | 2010-11-25 | — | — | US | disclosed |
| US-20070225290-A1 | Tetrahydronaphthalene derivates, processes for preparing them and their use as antiinflammatory agents | BAYER SCHERING PHARMA AG (DE) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225290-A1 | Tetrahydronaphthalene derivates, processes for preparing them and their use as antiinflammatory agents | TNF, IL1B, DHPS | ALDH1A1 306/4885KDM4E 4319/4885HSD17B10 536/4885 |
| US-20100298311-A1 | TETRAHYDRONAPHTHALENE DERIVATES, PROCESS FOR PREPARING THEM AND THEIR USE AS ANTIINFLAMMATORY AGENTS | TNF, IL1B, DHPS | ALDH1A1 309/4885KDM4E 4227/4885HSD17B10 516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.