⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3747659 | 0.78 | LTA4H (0.37) | — | |
| SCHEMBL3757935 | 0.75 | LTA4H (0.37) | — | |
| SCHEMBL3740697 | 0.74 | HTR2A (0.32) | — | |
| SCHEMBL3753909 | 0.64 | FADS1 (0.33) | — | |
| SCHEMBL3740673 | 0.64 | SLC18A3 (0.37) | — | |
| SCHEMBL3745652 | 0.64 | SLC18A3 (0.37) | — | |
| SCHEMBL13075741 | 0.63 | FADS1 (0.34) | — | |
| SCHEMBL3747277 | 0.63 | HTR3E (0.33) | — | |
| SCHEMBL3746341 | 0.62 | LTA4H (0.38) | — | |
| SCHEMBL3746339 | 0.62 | LTA4H (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132015-A1 | NEW COMPOUNDS MODULATING GAMMA-SECRETASE AND THEIR USE IN THE TREATMENT OF ALPHA BETA RELATED PATHOLOGIES, SUCH AS ALZHEIMER'S DISEASE | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292210-A1 | Novel Compounds for A-Beta-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292210-A1 | Novel Compounds for A-Beta-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |