Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3557651 | 0.81 | ALDH1A1 (0.43) | NOTUMKMT2AMEN1POLBP2RX7 | |
| SCHEMBL6328796 | 0.67 | NOTUM (0.42) | NOTUMP2RX7 | |
| SCHEMBL9107908 | 0.64 | P2RX7 (0.54) | NOTUMP2RX7CYP2C19 | |
| SCHEMBL9107918 | 0.64 | P2RX7 (0.54) | NOTUMP2RX7CYP2C19 | |
| SCHEMBL17940635 | 0.63 | P2RX7 (0.56) | KMT2AMEN1HTTP2RX7CYP2C19 | |
| SCHEMBL1614091 | 0.63 | P2RX7 (0.56) | KMT2AMEN1HTTP2RX7CYP2C19 | |
| SCHEMBL288496 | 0.63 | P2RX7 (0.56) | KMT2AMEN1HTTP2RX7CYP2C19 | |
| SCHEMBL11478087 | 0.62 | MDM2 (0.51) | KMT2AMEN1POLBHTT | |
| SCHEMBL9192753 | 0.61 | RAF1 (0.44) | NOTUMKMT2AMEN1POLB | |
| SCHEMBL9105586 | 0.61 | NOTUM (0.49) | NOTUMKMT2AMEN1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1810972-B1 | NITROGENOUS HETEROCYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | ONO PHARMACEUTICAL CO (JP) | 2012-01-25 | — | — | EP | disclosed |