SCHEMBL3752961

SCHEMBL3752961

CC(C)(C)[Si](C)(C)OCc1coc(-c2ccc(NC(=O)O)cc2F)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 3/20 0.42
IMPDH2 P12268 1/20 0.38
IMPDH1 P20839 1/20 0.38
LMNA P02545 1/20 0.36
AAK1 Q2M2I8 1/20 0.34
PPARG P37231 1/20 0.34
KMT2A Q03164 2/20 0.33
HPSE Q9Y251 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HSD17B10 Q99714 2/20 0.33
FFAR1 O14842 1/20 0.33
KDM4E B2RXH2 2/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
KDR P35968 1/20 0.32
MEN1 O00255 1/20 0.32
MAPT P10636 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
HPGD P15428 1/20 0.32
NFKB1 P19838 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13054797 0.87 PPARA (0.43) PPARAKMT2AALDH1A1NPC1RAB9A
SCHEMBL3763728 0.82 LMNA (0.44) PPARAIMPDH2IMPDH1LMNAAAK1
SCHEMBL3752965 0.74 IMPDH2 (0.37) PPARAIMPDH2IMPDH1LMNAAAK1
SCHEMBL19306519 0.73 KLK7 (0.41) KMT2AHSD17B10NPC1RAB9AMEN1
SCHEMBL22689537 0.73 BACE1 (0.35) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL3750701 0.73 PTGDR2 (0.41) PPARAKMT2AALDH1A1KDM4ENPC1
SCHEMBL13054794 0.71 MGLL (0.48) PPARAALDH1A1NPC1RAB9AMAPT
SCHEMBL3758261 0.70 CALML3 (0.55)
SCHEMBL17785067 0.70 TRPV1 (0.37) KMT2AALDH1A1KDM4ERAB9AMEN1
SCHEMBL4861321 0.69 MALT1 (0.34) KMT2AALDH1A1NPC1RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2010-11-25 US disclosed
WO-2008143649-A2 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LIMITED (IN) 2008-11-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS OXA1L, MIF, VIP PPARA 2195/4885IMPDH2 318/4885IMPDH1 187/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.