Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PLEC | Q15149 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PTPN12 | Q05209 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756338 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL2876298 | 0.87 | ALOX15 (0.58) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL2876296 | 0.87 | ALOX15 (0.58) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL918950 | 0.86 | KMT2A (0.50) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL919906 | 0.86 | POLB (0.51) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL2078910 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL918951 | 0.86 | KMT2A (0.50) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL919905 | 0.86 | POLB (0.51) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL11749888 | 0.86 | CA2 (0.61) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 | |
| SCHEMBL2078912 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2AKDM4EL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842684-B2 | 2-azetidinone derivatives such as N-({4-[(2R,3R)-3-{[(2R)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-1-(4-{3-[(methylsulfonyl)amino]prop-1-yn-1-yl}phenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-3-cyclohexyl-D-alanine, used for the treatment of hyperlipemia | ASTRAZENECA AB (SE) | 2010-11-30 | — | — | US | disclosed |
| US-20090069285-A1 | Diphenylazetidinone Derivatives Possessing Cholesterol Absorption Inhibitor Activity | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069285-A1 | Diphenylazetidinone Derivatives Possessing Cholesterol Absorption Inhibitor Activity | CYP46A1, NPC1L1, NPC1 | ALDH1A1 1232/4885KMT2A 1369/4885KDM4E 1492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.