Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741339 | 0.85 | SIRT6 (0.62) | MAPTALDH1A1HTTIGF1RSIRT6 | |
| SCHEMBL519813 | 0.82 | IGF1R (0.65) | MAPTALDH1A1HTTIGF1RSIRT6 | |
| SCHEMBL519461 | 0.82 | IGF1R (0.65) | MAPTALDH1A1HTTIGF1RSIRT6 | |
| SCHEMBL519460 | 0.82 | IGF1R (0.65) | MAPTALDH1A1HTTIGF1RSIRT6 | |
| SCHEMBL1045292 | 0.80 | SIRT6 (0.69) | MAPTALDH1A1SIRT6HTR1APOLB | |
| SCHEMBL374222 | 0.80 | SIRT6 (0.68) | MAPTALDH1A1SIRT6POLBLMNA | |
| SCHEMBL1046934 | 0.80 | HTR1A (0.65) | MAPTIGF1RSIRT6HTR1APOLB | |
| SCHEMBL7768027 | 0.79 | IGF1R (0.55) | MAPTALDH1A1HTTIGF1RSIRT6 | |
| SCHEMBL6945690 | 0.78 | SIRT6 (0.65) | MAPTALDH1A1SIRT6HTR1APOLB | |
| SCHEMBL15445827 | 0.77 | MAPT (0.66) | MAPTALDH1A1HTTTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173749-A1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | F2G Limited (GB) | 2010-04-14 | — | — | EP | disclosed |
| WO-2008145963-A1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | F2G LIMITED (GB) | 2008-12-04 | — | — | WO | disclosed |