Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741339 | 0.85 | SIRT6 (0.62) | IGF1RSIRT6MAPTALDH1A1HTT | |
| SCHEMBL519461 | 0.82 | IGF1R (0.65) | IGF1RSIRT6MAPTALDH1A1HTT | |
| SCHEMBL519813 | 0.82 | IGF1R (0.65) | IGF1RSIRT6MAPTALDH1A1HTT | |
| SCHEMBL519460 | 0.82 | IGF1R (0.65) | IGF1RSIRT6MAPTALDH1A1HTT | |
| SCHEMBL7766495 | 0.80 | AKR1C3 (0.45) | ALDH1A1 | |
| SCHEMBL3756774 | 0.79 | MAPT (0.56) | IGF1RSIRT6MAPTALDH1A1HTT | |
| SCHEMBL6367321 | 0.77 | SIRT6 (0.56) | SIRT6MAPTPOLBLMNAHTR1A | |
| SCHEMBL374222 | 0.77 | SIRT6 (0.68) | SIRT6MAPTALDH1A1POLBLMNA | |
| SCHEMBL1814960 | 0.77 | SIRT6 (0.59) | SIRT6MAPTALDH1A1POLBLMNA | |
| SCHEMBL1046934 | 0.77 | HTR1A (0.65) | IGF1RSIRT6MAPTPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104413-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | ELI LILLY AND COMPANY LIMITED (GB) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000008006-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | ELI LILLY AND COMPANY LIMITED (GB) | 2000-02-17 | — | — | WO | disclosed |