Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | LDHB | P07195 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | YWHAH | Q04917 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757153 | 0.87 | MAPK8 (0.47) | L3MBTL1SMN1; SMN2ALDH1A1NPSR1GAA | |
| SCHEMBL1884680 | 0.77 | NOTUM (0.51) | NOTUMCCR2LMNATSHRSMN1; SMN2 | |
| SCHEMBL1873898 | 0.74 | NOTUM (0.54) | NOTUMCCR2LMNATSHRSMN1; SMN2 | |
| SCHEMBL1875953 | 0.74 | NOTUM (0.70) | NOTUMCCR2LMNATSHRSMN1; SMN2 | |
| SCHEMBL1887819 | 0.71 | NOTUM (0.51) | NOTUMCCR2LMNATSHRSMN1; SMN2 | |
| SCHEMBL1880697 | 0.70 | NOTUM (0.50) | NOTUMCCR2LMNATSHRSMN1; SMN2 | |
| SCHEMBL1880517 | 0.70 | MAPT (0.47) | NOTUML3MBTL1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL3759645 | 0.69 | MAPT (0.55) | L3MBTL1TSHRSMN1; SMN2ATMALDH1A1 | |
| SCHEMBL28829407 | 0.68 | GSK3A (0.41) | NOTUMCCR2LMNATSHRSMN1; SMN2 | |
| SCHEMBL1884573 | 0.68 | NOTUM (0.47) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185506-A1 | PYRROLE COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST OR ANTAGONIST BIOLOGICAL ACTIVITY | Allergan, Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009026407-A1 | PYRROLE COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST OR ANTAGONIST BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 2009-02-26 | — | — | WO | disclosed |