Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435903 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL31036835 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| Hydrazine SCHEMBL28365317 | 0.77 | L3MBTL1 (0.54) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL9065871 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL29582316 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL5041519 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL84051 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL29401687 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL29424134 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL864064 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178375-B1 | PYRAZOLOÝ1,5-A¨PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME (US) | 2014-09-24 | — | — | EP | disclosed |
| US-8461162-B2 | Pyrazolo[1,5-a]pyrimidine derivatives | MERCK SHARP & DOHME CORP. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MERCK SHARP & DOHME LLC | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305091-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | MAPT, TTBK1, TTBK2 | SMN1; SMN2 473/4885L3MBTL1 2518/4885NOS3 3494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.