Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 13/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.57 |
| ▸ | POLB | P06746 | 10/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | GALK1 | P51570 | 1/20 | 0.53 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.50 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.48 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757779 | 1.00 | NR4A1 (0.64) | NR4A1MEN1KMT2APOLBMAPT | |
| SCHEMBL3755954 | 0.88 | ITGA4 (0.65) | NR4A1MEN1KMT2APOLBMAPT | |
| SCHEMBL3755958 | 0.88 | ITGA4 (0.65) | NR4A1MEN1KMT2APOLBMAPT | |
| SCHEMBL5734258 | 0.87 | ABL1 (0.64) | NR4A1MEN1KMT2APOLBMAPT | |
| SCHEMBL5734261 | 0.87 | ABL1 (0.64) | NR4A1MEN1KMT2APOLBMAPT | |
| SCHEMBL5735689 | 0.86 | NR4A1 (0.63) | NR4A1MEN1KMT2APOLBMAPT | |
| SCHEMBL5735693 | 0.86 | NR4A1 (0.63) | NR4A1MEN1KMT2APOLBMAPT | |
| SCHEMBL13856167 | 0.78 | NR4A1 (1.00) | NR4A1MEN1KMT2APOLBMAPT | |
| SCHEMBL5735622 | 0.78 | NR4A1 (0.76) | NR4A1MEN1KMT2APOLBMAPT | |
| SCHEMBL5735625 | 0.78 | NR4A1 (0.76) | NR4A1MEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120289569-A1 | INHIBITORS OF UBIQUITIN E1 | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-11-15 | — | — | US | disclosed |
| US-8242160-B2 | Inhibitors of ubiquitin E1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-08-14 | — | — | US | disclosed |
| US-20100305180-A1 | INHIBITORS OF UBIQUITIN E1 | WEISSMAN ALLAN M | 2010-12-02 | — | — | US | disclosed |
| US-20080306130-A1 | Inhibitors of ubiquitin E1 | GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-12-11 | — | — | US | disclosed |
| WO-2007059356-A2 | FURFURYLIDENE- PYRAZOLIDINES AND THEIR USE AS INHIBITORS OF UBIQUITIN E1 | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306130-A1 | Inhibitors of ubiquitin E1 | CUL1, UBQLN1, UBE2E1 | NR4A1 3205/4885MEN1 1989/4885KMT2A 1070/4885 |
| US-20120289569-A1 | INHIBITORS OF UBIQUITIN E1 | CUL1, UBQLN1, UBE2E1 | NR4A1 3205/4885MEN1 1989/4885KMT2A 1070/4885 |
| US-20100305180-A1 | INHIBITORS OF UBIQUITIN E1 | CUL1, UBQLN1, UBE2E1 | NR4A1 3205/4885MEN1 1989/4885KMT2A 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.