Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.63 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.56 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.56 |
| ▸ | MEN1 | O00255 | 12/20 | 0.56 |
| ▸ | POLB | P06746 | 10/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.56 |
| ▸ | GFER | P55789 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 5/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5735689 | 1.00 | NR4A1 (0.63) | NR4A1ITGA4ITGB7KMT2AMEN1 | |
| SCHEMBL3755958 | 0.92 | ITGA4 (0.65) | NR4A1ITGA4ITGB7KMT2AMEN1 | |
| SCHEMBL3755954 | 0.92 | ITGA4 (0.65) | NR4A1ITGA4ITGB7KMT2AMEN1 | |
| SCHEMBL5734258 | 0.86 | ABL1 (0.64) | NR4A1ITGA4ITGB7KMT2AMEN1 | |
| SCHEMBL3757779 | 0.86 | NR4A1 (0.64) | NR4A1ITGA4ITGB7KMT2AMEN1 | |
| SCHEMBL3757780 | 0.86 | NR4A1 (0.64) | NR4A1ITGA4ITGB7KMT2AMEN1 | |
| SCHEMBL5734261 | 0.86 | ABL1 (0.64) | NR4A1ITGA4ITGB7KMT2AMEN1 | |
| SCHEMBL5735121 | 0.78 | KMT2A (0.66) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL5735117 | 0.78 | KMT2A (0.66) | KMT2AMEN1POLBMAPTALDH1A1 | |
| SCHEMBL5735625 | 0.77 | NR4A1 (0.76) | NR4A1KMT2AMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014120683-A1 | SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2014-08-07 | — | — | WO | claimed |
| EP-1399156-B1 | ALKYLIDENE PIRAZOLIDINEDIONE DERIVATIVES AND THEIR USE FOR TREATING DIABETES AND OBESITY | APPLIED RESEARCH SYSTEMS (AN) | 2006-11-22 | — | — | EP | claimed |
| US-20040220188-A1 | Alkylidene pyrazolidinedione derivatives | LABORATOIRES SERONO SA (CH) | 2004-11-04 | — | — | US | claimed |
| US-9951024-B2 | Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170349553-A1 | SMALL- MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS | UNIVERSITY OF CINCINNATI | 2017-12-07 | — | — | US | disclosed |
| US-20160083353-A1 | SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-24 | — | — | US | disclosed |
| WO-2014120683-A1 | SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2014-08-07 | — | — | WO | disclosed |
| EP-1399156-B1 | ALKYLIDENE PIRAZOLIDINEDIONE DERIVATIVES AND THEIR USE FOR TREATING DIABETES AND OBESITY | APPLIED RESEARCH SYSTEMS (AN) | 2006-11-22 | — | — | EP | disclosed |
| US-20040220188-A1 | Alkylidene pyrazolidinedione derivatives | LABORATOIRES SERONO SA (CH) | 2004-11-04 | — | — | US | disclosed |
| EP-1399156-A2 | ALKYLIDENE PIRAZOLIDINEDIONE DERIVATIVES AND THEIR USE FOR TREATING DIABETES AND OBESITY | Applied Research Systems ARS Holding N.V. (AN) | 2004-03-24 | — | — | EP | disclosed |
| WO-2002102359-A2 | ALKYLIDENE PYRAZOLIDINEDIONE DERIVATIVES AND USE FOR TREATING DIABETES AND OBESITY | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2002-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083353-A1 | SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS | ARHGEF1, ARHGEF2, ARHGDIB | NR4A1 4748/4885ITGA4 3010/4885ITGB7 1868/4885 |
| US-20040220188-A1 | Alkylidene pyrazolidinedione derivatives | G6PC1, PPM1D, PTPRS | NR4A1 2744/4885ITGA4 4401/4885ITGB7 4533/4885 |
| US-20170349553-A1 | SMALL- MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS | ARHGEF1, ARHGEF2, ARHGDIB | NR4A1 4748/4885ITGA4 3010/4885ITGB7 1868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.