Androstenedone

Androstenedone

SCHEMBL3758714

CC12C=CC(=O)C=C1CCC1C2CCC2(C)C(=O)CCC12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 17/20 1.00
CYP3A4 P08684 1/20 1.00
LMNA P02545 2/20 0.66
MAPT P10636 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Androstenedone SCHEMBL134061 1.00 CYP19A1 (1.00) CYP19A1CYP3A4LMNAMAPT
Androstenedone SCHEMBL1144460 1.00 CYP19A1 (1.00) CYP19A1CYP3A4LMNAMAPT
Androstenedone SCHEMBL172864 1.00 CYP19A1 (1.00) CYP19A1CYP3A4LMNAMAPT
Androstenedone SCHEMBL12430773 1.00 CYP19A1 (1.00) CYP19A1CYP3A4LMNAMAPT
Androstenedone SCHEMBL14450072 1.00 CYP19A1 (1.00) CYP19A1CYP3A4LMNAMAPT
Androstenedone SCHEMBL10597170 0.99 CYP19A1 (0.97) CYP19A1CYP3A4LMNAMAPT
Androstenedone SCHEMBL4266758 0.92 CYP19A1 (0.84) CYP19A1CYP3A4LMNA
SCHEMBL6897786 0.88 CYP19A1 (0.79) CYP19A1CYP3A4LMNAMAPT
SCHEMBL8491921 0.86 CYP19A1 (0.76) CYP19A1CYP3A4LMNA
SCHEMBL6999301 0.86 CYP19A1 (0.76) CYP19A1CYP3A4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8227208-B2 Process for the enantioselective reduction and oxidation, respectively, of steroids IEP GMBH (DE) 2012-07-24 US disclosed
US-8227208-B2 Process for the enantioselective reduction and oxidation, respectively, of steroids IEP GMBH (DE) 2012-07-24 US disclosed
EP-2004838-B1 PROCESS FOR THE PREPARATION OF STEROID DERIVATIVES BY REDUCTION OF OXOSTEROID COMPOUNDS OR BY OXIDATION OF HYDROXYSTEROID COMPOUNDS USING A HYDROXYSTEROID DEHYDROGENASE IEP GMBH (DE) 2012-06-13 EP disclosed
EP-1507867-B1 PROCESS FOR FERMENTATION OF PHYTOSTEROLS TO ANDROSTADIENEDIONE ORGANON NV (NL) 2011-08-03 EP disclosed
US-20100323390-A1 Method for the Identification of a Metabolic Pathway Family by Means of Positive Selection LIBRAGEN (FR) 2010-12-23 US disclosed
US-7846874-B2 Method for the identification of a metabolic pathway family by means of positive selection LIBRAGEN (FR) 2010-12-07 US disclosed
US-20090280525-A1 PROCESS FOR THE ENANTIOSELECTIVE REDUCTION AND OXIDATION, RESPECTIVELY, OF STEROIDS IEP GMBH (DE) 2009-11-12 US disclosed
US-20090280525-A1 PROCESS FOR THE ENANTIOSELECTIVE REDUCTION AND OXIDATION, RESPECTIVELY, OF STEROIDS IEP GMBH (DE) 2009-11-12 US disclosed
EP-1730296-B1 METHOD FOR THE IDENTIFICATION OF A METABOLIC PATHWAY FAMILY BY MEANS OF POSITIVE SELECTION LIBRAGEN (FR) 2009-06-10 EP disclosed
US-20090137541-A1 Novel Series of Imidazolyl Substituted Steroidal and Indan-1-One Derivatives COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2009-05-28 US disclosed
US-20090137541-A1 Novel Series of Imidazolyl Substituted Steroidal and Indan-1-One Derivatives COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2009-05-28 US disclosed
WO-2007118644-A1 PROCESS FOR THE PREPARATION OF STEROID DERIVATIVES BY REDUCTION OF OXOSTEROID COMPOUNDS OR BY OXIDATION OF HYDROXYSTEROID COMPOUNDS USING A HYDROXYSTEROID DEHYDROGENASE IEP GMBH (DE) 2007-10-25 WO disclosed
US-20070184449-A1 Method for the identification of a metabolic pathway family by means of positive selection LIBRAGEN (FR) 2007-08-09 US disclosed
EP-1730296-A1 METHOD FOR THE IDENTIFICATION OF A METABOLIC PATHWAY FAMILY BY MEANS OF POSITIVE SELECTION Libragen (FR) 2006-12-13 EP disclosed
WO-2005095634-A1 METHOD FOR THE IDENTIFICATION OF A METABOLIC PATHWAY FAMILY BY MEANS OF POSITIVE SELECTION LIBRAGEN (FR) 2005-10-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137541-A1 Novel Series of Imidazolyl Substituted Steroidal and Indan-1-One Derivatives NR5A1, NR3C2, CYP17A1 CYP19A1 13/4885CYP3A4 119/4885LMNA 2600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.