Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TNF | P01375 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25395368 | 0.87 | MAPT (0.46) | MAPTHTTALDH1A1TNFLMNA | |
| SCHEMBL25396424 | 0.83 | KMT2A (0.40) | MAPTHTTALDH1A1LMNARAB9A | |
| SCHEMBL5939919 | 0.81 | MAPT (0.49) | MAPTALDH1A1LMNATHRBKMT2A | |
| SCHEMBL25394336 | 0.80 | NOTUM (0.47) | MAPTTNFRENL3MBTL1KMT2A | |
| SCHEMBL4256753 | 0.79 | HTT (0.58) | MAPTHTTTHRBTP53USP2 | |
| SCHEMBL5710197 | 0.78 | REN (0.54) | MAPTALDH1A1LMNATHRBREN | |
| SCHEMBL6684778 | 0.78 | CHRM2 (0.52) | TNFREN | |
| SCHEMBL5940159 | 0.78 | MAPT (0.39) | MAPTHTTALDH1A1TNFLMNA | |
| SCHEMBL23455573 | 0.77 | MAPT (0.45) | MAPTHTTALDH1A1LMNARAB9A | |
| SCHEMBL3765131 | 0.76 | PTGER3 (0.46) | ALDH1A1LMNATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8679776-B2 | Activatable dyes | UNIVERSITY OF MASSACHUSETTS (US) | 2014-03-25 | — | — | US | disclosed |
| US-20100297684-A1 | ACTIVATIBLE DYES | UNIVERSITY OF MASSACHUSETTS | 2010-11-25 | — | — | US | disclosed |
| US-20070031336-A1 | 3H-phenoxazine derivatives suitable as near-infrared imaging agents, preparation an use thereof | NOVARTIS AG (CH) | 2007-02-08 | — | — | US | disclosed |
| EP-1658294-B1 | 3H-PHENOXAZINE DERIVATIVES SUITABLE AS NEAR-INFRARED IMAGING AGENTS, PREPARATION AN USE THEREOF | NOVARTIS AG (CH) | 2007-01-10 | — | — | EP | disclosed |
| EP-1658294-A1 | 3H-PHENOXAZINE DERIVATIVES SUITABLE AS NEAR-INFRARED IMAGING AGENTS, PREPARATION AN USE THEREOF | Novartis AG (CH) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005016934-A1 | 3H-PHENOXAZINE DERIVATIVES SUITABLE AS NEAR-INFRARED IMAGING AGENTS, PREPARATION AN USE THEREOF | NOVARTIS AG (CH) | 2005-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297684-A1 | ACTIVATIBLE DYES | IK, MB, HMBS | MAPT 3995/4885HTT 1655/4885ALDH1A1 856/4885 |
| US-20070031336-A1 | 3H-phenoxazine derivatives suitable as near-infrared imaging agents, preparation an use thereof | PSEN1, PSEN2, CHRM5 | MAPT 332/4885HTT 545/4885ALDH1A1 4429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.