SCHEMBL375956

SCHEMBL375956

Cc1ncc2[nH]cnc2n1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.59
KDM4E B2RXH2 1/20 0.59
CDK2 P24941 2/20 0.46
RXFP1 Q9HBX9 1/20 0.46
PAK1 Q13153 1/20 0.44
POLA1 P09884 1/20 0.40
CCNT1 O60563 1/20 0.39
CDK1 P06493 1/20 0.39
CCNB1 P14635 1/20 0.39
CDK7 P50613 1/20 0.39
CDK9 P50750 1/20 0.39
CCNH P51946 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.36
PDK2 Q15119 1/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
ADORA1 P30542 1/20 0.32
MAP3K7 O43318 1/20 0.32
MAP3K6 O95382 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL27309824 0.98 ALDH1A1 (0.57) ALDH1A1KDM4ECDK2RXFP1PAK1
Phenethylamine SCHEMBL27612223 0.79 CDK2 (0.45) ALDH1A1KDM4ECDK2RXFP1POLA1
SCHEMBL7663294 0.78 ALDH1A1 (0.59) ALDH1A1KDM4ECDK2RXFP1PAK1
SCHEMBL3578267 0.78 ALDH1A1 (0.53) ALDH1A1KDM4ECDK2RXFP1PAK1
SCHEMBL29452971 0.77 ALDH1A1 (0.63) ALDH1A1KDM4ECDK2RXFP1PAK1
SCHEMBL5748057 0.76 ALDH1A1 (0.61) ALDH1A1KDM4ECDK2RXFP1PAK1
SCHEMBL31058752 0.75 KDM4E (0.50) ALDH1A1KDM4ECDK2RXFP1PAK1
SCHEMBL357005 0.74 KDM4E (1.00) ALDH1A1KDM4ECDK2RXFP1PAK1
SCHEMBL3896 0.74 ALDH1A1 (0.59) ALDH1A1KDM4ECDK2RXFP1PAK1
SCHEMBL408916 0.74 ALDH1A1 (0.59) ALDH1A1KDM4ECDK2RXFP1PAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 798 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4739788-A1 COMPOSITION COMPRISING MODIFIED DNA IDENTIFIER SEQUENCES FOR DNA MODIFICATION SCREENING ETH Zurich (CH) 2026-05-13 EP claimed
US-20250283063-A1 NOVEL CRISPR-CAS12I SYSTEMS AND USES THEREOF HUIDAGENE THERAPEUTICS CO., LTD. (CN) 2025-09-11 US claimed
EP-4514954-A1 NOVEL CRISPR-CAS12I SYSTEMS AND USES THEREOF Huidagene Therapeutics (Singapore) Pte. Ltd. (SG) 2025-03-05 EP claimed
EP-4514953-A1 NOVEL CRISPR-CAS12F SYSTEMS AND USES THEREOF Huidagene Therapeutics (Singapore) Pte. Ltd. (SG) 2025-03-05 EP claimed
CN-119421948-A Novel CRISPR-Cas12f system and application thereof 辉大(上海)生物科技有限公司 2025-02-11 CN claimed
CN-119331309-A Methyl purine ferulic acid aromatized water magnesite composite material and preparation method and application thereof 江西广源化工有限责任公司 2025-01-21 CN claimed
WO-2025012092-A1 COMPOSITION COMPRISING MODIFIED DNA IDENTIFIER SEQUENCES FOR DNA MODIFICATION SCREENING ETH ZURICH (CH) 2025-01-16 WO claimed
EP-4488381-A1 MODIFIED DNA IDENTIFIER SEQUENCES FOR DNA MODIFICATION SCREENING ETH Zurich (CH) 2025-01-08 EP claimed
CN-118931997-A Method for synthesizing adenosine and/or uridine by three-enzyme cascade catalysis 上海飞腾医药科技有限公司 2024-11-12 CN claimed
CN-118749029-A Novel CRISPR-Cas12i system and application thereof 辉大(上海)生物科技有限公司 2024-10-08 CN claimed
EP-1499628-A4 RNA INTERFERENCE MEDIATED INHIBITION OF STEAROYL-COA DESATURASE (SCD) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) SIRNA THERAPEUTICS INC (US) 2005-06-15 EP claimed
EP-1515985-A2 METHODS OF SCREENING MOLECULAR LIBRARIES FOR ACTIVE MOLECULES THAT RESTORE THE FUNCTION OF MUTANT P53 El-Gewely, Mohammed Raafat (NO) 2005-03-23 EP claimed
EP-1499628-A2 RNA INTERFERENCE MEDIATED INHIBITION OF STEAROYL-COA DESATURASE (SCD) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) Sirna Therapeutics, Inc. (US) 2005-01-26 EP claimed
EP-1499631-A2 RNA INTERFERENCE MEDIATED INHIBITION OF TGF-BETA AND TGF-BETA RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) Sirna Therapeutics, Inc. (US) 2005-01-26 EP claimed
WO-2003072600-A2 METHODS OF SCREENING MOLECULAR LIBRARIES FOR ACTIVE MOLECULES THAT RESTORE THE FUNCTION OF TARGET PROTEINS AND PEPTIDES THAT RESTORE THE FUNCTION OF MUTANT P53 GARDNER, REBECCA, KATHERINE (GB) 2003-09-04 WO claimed
WO-2003070885-A2 SHORT INTERFERING NUCLEIC ACID INHIBITION OF STEAROYL-CoA DESATURASE (SCD) GENE SIRNA THERAPEUTICS, INC. (US) 2003-08-28 WO claimed
WO-2003070197-A2 RNA INTERFERENCE MEDIATED INHIBITION OF TGF-BETA AND TGF-BETA RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) SIRNA THERAPEUTICS, INC. (US) 2003-08-28 WO claimed
US-20030134819-A1 Recombinant bacterial cells for delivery of PNP to tumor cells SOUTHERN RESEARCH INSTITUTE 2003-07-17 US claimed
CN-1172417-A Feed for fishes and shellfishes PROD DEV RES INST (JP) 1998-02-04 CN claimed
US-4925901-A STORAGE STAABILITY, ONIUM ION CATALYST THE DOW CHEMICAL COMPANY (US) 1990-05-15 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250283063-A1 NOVEL CRISPR-CAS12I SYSTEMS AND USES THEREOF RBM12, PRR12, HM13 ALDH1A1 4821/4885KDM4E 4769/4885CDK2 4126/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.