Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5540994 | 0.81 | CLK4 (0.52) | DYRK1ACLK4CYP19A1SMN1; SMN2NPC1 | |
| SCHEMBL4278798 | 0.81 | LMNA (0.46) | FYNMAPT | |
| SCHEMBL16471822 | 0.80 | CCR1 (0.68) | DYRK1ACLK4CYP19A1SMN1; SMN2TOP1 | |
| SCHEMBL29496945 | 0.78 | DYRK1A (0.66) | DYRK1ACLK4CYP19A1SMN1; SMN2TOP1 | |
| SCHEMBL183897 | 0.78 | DYRK1A (0.66) | DYRK1ACLK4CYP19A1SMN1; SMN2TOP1 | |
| SCHEMBL1416518 | 0.77 | CLK4 (0.51) | DYRK1ACLK4CYP19A1SMN1; SMN2TOP1 | |
| SCHEMBL5537490 | 0.77 | ALDH1A1 (0.51) | SMN1; SMN2NPC1PKMRAB9AFYN | |
| SCHEMBL6831093 | 0.77 | DYRK1A (0.64) | DYRK1ACLK4CYP19A1SMN1; SMN2TOP1 | |
| SCHEMBL2485408 | 0.77 | DYRK1A (0.64) | DYRK1ACLK4CYP19A1SMN1; SMN2TOP1 | |
| SCHEMBL2431863 | 0.76 | CCR1 (0.58) | DYRK1ACLK4CYP19A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987309-B2 | Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-03-24 | — | — | US | disclosed |
| US-20120136029-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 2-ARYL PYRIDYLAZOLES | UNIVERSITY OF ARIZONA (US) | 2012-05-31 | — | — | US | disclosed |
| WO-2010121243-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 2-ARYL PYRIDYLAZOLES | UNIVERSITY OF ARIZONA (US) | 2010-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136029-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 2-ARYL PYRIDYLAZOLES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CDK2, CCNC | DYRK1A 4093/4885CLK4 2884/4885CYP19A1 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.