Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 3/20 | 0.78 |
| ▸ | HTR2C | P28335 | 8/20 | 0.71 |
| ▸ | BCDIN3D | Q7Z5W3 | 6/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943320 | 0.91 | SHMT2 (0.78) | SHMT2HTR2CBCDIN3DMAPTKDM4E | |
| SCHEMBL13942965 | 0.90 | SHMT2 (0.77) | SHMT2HTR2CBCDIN3DMAPTKDM4E | |
| SCHEMBL13944360 | 0.88 | SHMT2 (1.00) | SHMT2HTR2CBCDIN3DMAPTKDM4E | |
| SCHEMBL3756412 | 0.87 | HTR2C (0.75) | SHMT2HTR2CBCDIN3DMAPTKDM4E | |
| SCHEMBL12982853 | 0.84 | SHMT2 (0.78) | SHMT2HTR2CBCDIN3DMAPTKDM4E | |
| SCHEMBL3755109 | 0.83 | HTR2C (1.00) | HTR2CBCDIN3DHTR2AMAPTTP53 | |
| SCHEMBL13944190 | 0.83 | HTR2C (1.00) | SHMT2HTR2CBCDIN3DMAPTKDM4E | |
| SCHEMBL13944750 | 0.82 | SHMT2 (0.72) | SHMT2HTR2CBCDIN3DMAPTTP53 | |
| SCHEMBL13942978 | 0.82 | HTR2C (1.00) | SHMT2HTR2CBCDIN3DHTR2AMAPT | |
| SCHEMBL3753369 | 0.82 | SYK (0.71) | SHMT2HTR2CBCDIN3DMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232279-B2 | Pyrazolopyrimidine derivatives having biological activity on serotonin receptor 5-HT2c | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-07-31 | — | — | US | claimed |
| US-20100298563-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES HAVING BIOLOGICAL ACTIVITY ON SEROTONIN RECEPTOR 5-HT2c | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-11-25 | — | — | US | claimed |
| US-8232279-B2 | Pyrazolopyrimidine derivatives having biological activity on serotonin receptor 5-HT2c | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-07-31 | — | — | US | disclosed |
| US-20100298563-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES HAVING BIOLOGICAL ACTIVITY ON SEROTONIN RECEPTOR 5-HT2c | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-11-25 | — | — | US | disclosed |
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298563-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES HAVING BIOLOGICAL ACTIVITY ON SEROTONIN RECEPTOR 5-HT2c | HTR2C, HTR5A, HTR3C | SHMT2 1598/4885HTR2C 1/4885BCDIN3D 4038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.