SCHEMBL3762081

SCHEMBL3762081

CP(=O)(O)N(c1ccc2[nH]ccc2c1)S(=O)(=O)c1cc(Cl)cc(Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F7 P08709 1/20 0.39
LTA4H P09960 1/20 0.39
F3 P13726 1/20 0.39
AHR P35869 1/20 0.39
NR4A2 P43354 1/20 0.39
NPC1 O15118 3/20 0.38
PER2 O15055 1/20 0.35
CRY1 Q16526 1/20 0.35
CRY2 Q49AN0 1/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35
MAPT P10636 3/20 0.34
RAB9A P51151 2/20 0.34
SLC6A2 P23975 3/20 0.33
SLC6A4 P31645 3/20 0.33
SLC6A3 Q01959 3/20 0.33
USP2 O75604 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3021280 0.81 PER2 (0.39) F7LTA4HF3AHRNR4A2
SCHEMBL10292752 0.77 PER2 (0.37) F7LTA4HF3AHRNR4A2
SCHEMBL3804593 0.75 NR4A2 (0.38) F7F3NR4A2MAPTGAA
SCHEMBL2850695 0.74 TP53 (0.44) F7LTA4HF3AHRNR4A2
SCHEMBL10260632 0.74 LMNA (0.37) F7LTA4HF3AHRNR4A2
SCHEMBL3040300 0.74 ESR1 (0.39) F7LTA4HF3AHRNR4A2
SCHEMBL3300480 0.73 PTGS2 (0.37) F7LTA4HF3AHRNR4A2
SCHEMBL11948414 0.72 HCRTR2 (0.44) PER2CRY1CRY2RAB9AUSP2
SCHEMBL11948410 0.72 PER2 (0.38) F7LTA4HF3AHRNR4A2
SCHEMBL13941196 0.70 PER2 (0.37) F7LTA4HF3AHRNR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2185572-A1 SUBSTITUTED ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF TYPE I AND II DIABETES MELLITUS Boehringer Ingelheim International GmbH (DE) 2010-05-19 EP disclosed
WO-2009016119-A1 SUBSTITUTED ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF TYPE I AND II DIABETES MELLITUS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-02-05 WO disclosed