Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.58 |
| ▸ | MEN1 | O00255 | 10/20 | 0.58 |
| ▸ | RECQL | P46063 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | THRB | P10828 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.58 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.53 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.53 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | BLM | P54132 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762869 | 1.00 | MAPT (0.61) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL3766201 | 0.87 | MAPT (0.71) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL14432335 | 0.87 | MAPT (0.71) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL3766205 | 0.87 | MAPT (0.71) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL3763335 | 0.73 | MAPT (0.74) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL3763333 | 0.73 | MAPT (0.74) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL3766211 | 0.70 | GPR55 (0.46) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL3766218 | 0.70 | GPR55 (0.46) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL11745227 | 0.66 | CYP19A1 (0.72) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL11745232 | 0.66 | CYP19A1 (0.72) | MAPTALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | MAPT 4500/4885KDM4E 2546/4885ALDH1A1 1386/4885 |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | MAPT 4500/4885KDM4E 2546/4885ALDH1A1 1386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.