SCHEMBL376418

SCHEMBL376418

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.36
▸ PDE4A P27815 1/20 0.36
▸ LMNA P02545 2/20 0.34
▸ PYGL P06737 7/20 0.33
▸ GRIK1 P39086 1/20 0.33
▸ GRIK2 Q13002 1/20 0.33
▸ NPFFR2 Q9Y5X5 2/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ G6PC1 P35575 1/20 0.32
▸ DPEP1 P16444 1/20 0.32
▸ CYP1A2 P05177 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28173815 1.00 ALDH1A1 (0.36) ALDH1A1PDE4ALMNAPYGLGRIK1
SCHEMBL376014 0.95 ALDH1A1 (0.37) ALDH1A1PYGLGRIK1GRIK2NPFFR2
SCHEMBL1406219 0.89 ALDH1A1 (0.44) ALDH1A1PYGLGRIK1GRIK2NPFFR2
SCHEMBL376017 0.87 CYP3A4 (0.33) PDE4ALMNAKMT2ATDP1
SCHEMBL27420276 0.87 CYP3A4 (0.33) PDE4ALMNAKMT2ATDP1
SCHEMBL28654142 0.87 PDE4A (0.33) PDE4ALMNAKMT2ATDP1
SCHEMBL376118 0.84 CYP3A4 (0.35) ALDH1A1LMNAKMT2ATDP1
SCHEMBL27476451 0.84 CYP3A4 (0.35) ALDH1A1LMNAKMT2ATDP1
SCHEMBL5069345 0.83 PDE4A (0.43) ALDH1A1PDE4ALMNAGRIK1L3MBTL1
SCHEMBL20506870 0.83 PDE4A (0.43) ALDH1A1PDE4ALMNAGRIK1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408892-B1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE SORBITOL ACETAL DERIVATIVES PROCTER & GAMBLE (US) 2016-01-06 — — EP claimed
EP-2408893-B1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE POLYOL ACETAL DERIVATIVES AND DETERSIVE ENZYMES PROCTER & GAMBLE (US) 2013-04-17 — — EP claimed
US-8293697-B2 Structured fluid detergent compositions comprising dibenzylidene sorbitol acetal derivatives THE PROCTER & GAMBLE COMPANY (US) 2012-10-23 — — US claimed
US-8153574-B2 Structured fluid detergent compositions comprising dibenzylidene polyol acetal derivatives and detersive enzymes THE PROCTER & GAMBLE COMPANY (US) 2012-04-10 — — US claimed
EP-2408892-A1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE SORBITOL ACETAL DERIVATIVES The Procter & Gamble Company (US) 2012-01-25 — — EP claimed
EP-2408893-A1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE POLYOL ACETAL DERIVATIVES AND DETERSIVE ENZYMES The Procter & Gamble Company (US) 2012-01-25 — — EP claimed
US-20100240569-A1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE SORBITOL ACETAL DERIVATIVES PROCTER & GAMBLE COMPANY, THE 2010-09-23 — — US claimed
US-20100240571-A1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE POLYOL ACETAL DERIVATIVES AND DETERSIVE ENZYMES PROCTER & GAMBLE COMPANY, THE 2010-09-23 — — US claimed
WO-2010108002-A1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE SORBITOL ACETAL DERIVATIVES THE PROCTER & GAMBLE COMPANY (US) 2010-09-23 — — WO claimed
WO-2010108000-A1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE POLYOL ACETAL DERIVATIVES AND DETERSIVE ENZYMES THE PROCTER & GAMBLE COMPANY (US) 2010-09-23 — — WO claimed
EP-2408892-B1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE SORBITOL ACETAL DERIVATIVES PROCTER & GAMBLE (US) 2016-01-06 — — EP disclosed
EP-2408893-B1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE POLYOL ACETAL DERIVATIVES AND DETERSIVE ENZYMES PROCTER & GAMBLE (US) 2013-04-17 — — EP disclosed
US-8293697-B2 Structured fluid detergent compositions comprising dibenzylidene sorbitol acetal derivatives THE PROCTER & GAMBLE COMPANY (US) 2012-10-23 — — US disclosed
US-8153574-B2 Structured fluid detergent compositions comprising dibenzylidene polyol acetal derivatives and detersive enzymes THE PROCTER & GAMBLE COMPANY (US) 2012-04-10 — — US disclosed
EP-2408892-A1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE SORBITOL ACETAL DERIVATIVES The Procter & Gamble Company (US) 2012-01-25 — — EP disclosed
US-20100240571-A1 STRUCTURED FLUID DETERGENT COMPOSITIONS COMPRISING DIBENZYLIDENE POLYOL ACETAL DERIVATIVES AND DETERSIVE ENZYMES PROCTER & GAMBLE COMPANY, THE 2010-09-23 — — US disclosed
EP-0945452-B1 SUGAR COMPOUNDS, GELLING AGENTS, GELLING AGENT COMPOSITIONS, PROCESSES FOR THE PREPARATION OF THEM, AND GEL COMPOSITIONS NEW JAPAN CHEM CO LTD (JP) 2003-11-19 — — EP disclosed
US-20030008953-A1 Asymmetric dipolar multi-substituted alditol derivatives, methods of making thereof, and compositions and articles containing same MILLIKEN & COMPANY 2003-01-09 — — US disclosed
US-6187842-B1 REACTING SORBITOL OR XYLITOL WITH BENZALDEHYE IN PRESENCE OF ACID CATALYST NEW JAPAN CHEMICAL CO., LTD. (JP) 2001-02-13 — — US disclosed
EP-0945452-A1 SUGAR COMPOUNDS, GELLING AGENTS, GELLING AGENT COMPOSITIONS, PROCESSES FOR THE PREPARATION OF THEM, AND GEL COMPOSITIONS NEW JAPAN CHEMICAL CO.,LTD. (JP) 1999-09-29 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030008953-A1 Asymmetric dipolar multi-substituted alditol derivatives, methods of making thereof, and compositions and articles containing same DERA, SORD, ALDOA ALDH1A1 31/4885PDE4A 1479/4885LMNA 2255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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