Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | FABP3 | P05413 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376529 | 0.86 | BCL2L1 (0.40) | MRGPRX4MEN1KMT2AHTTRORC | |
| SCHEMBL376254 | 0.76 | ALDH1A1 (0.45) | MEN1KMT2AHTTMAPTTP53 | |
| SCHEMBL17848532 | 0.73 | RIPK1 (0.46) | MEN1KMT2AHTTMETAP2RAB9A | |
| SCHEMBL28804991 | 0.73 | IP6K1 (0.56) | MRGPRX4MEN1KMT2AHTTRAB9A | |
| SCHEMBL11250568 | 0.71 | DPP4 (0.44) | MEN1KMT2AMETAP2RAB9AGRIN2B | |
| SCHEMBL5239394 | 0.71 | ALDH1A1 (0.63) | MEN1KMT2ARAB9AMAPTKDM4E | |
| SCHEMBL22551217 | 0.71 | KDM4E (0.49) | HTTMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL11255386 | 0.70 | RIPK1 (0.61) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL27805528 | 0.70 | USP2 (0.43) | MRGPRX4MEN1KMT2ARORCMAPT | |
| SCHEMBL7133586 | 0.69 | NPC1 (0.53) | KMT2ARAB9AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765778-B1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2012-01-25 | — | — | EP | disclosed |