Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 16/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 16/20 | 0.67 |
| ▸ | RECQL | P46063 | 15/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 11/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 10/20 | 0.67 |
| ▸ | MITF | O75030 | 9/20 | 0.67 |
| ▸ | PKM | P14618 | 6/20 | 0.67 |
| ▸ | GFER | P55789 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 13/20 | 0.64 |
| ▸ | POLB | P06746 | 9/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | HTT | P42858 | 5/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | XBP1 | P17861 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | NSD2 | O96028 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765392 | 1.00 | MEN1 (0.67) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL4797481 | 0.84 | MEN1 (0.57) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL15347317 | 0.83 | MAPT (0.65) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL15347315 | 0.83 | MAPT (0.65) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL12218053 | 0.83 | MAPT (0.65) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL26458992 | 0.77 | MEN1 (1.00) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL14712893 | 0.74 | MEN1 (0.74) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL3610125 | 0.71 | ITGA4 (0.69) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL14712884 | 0.71 | F2 (0.78) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL14564013 | 0.70 | ITGA4 (0.66) | MEN1KMT2ARECQLNPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | MEN1 3665/4885KMT2A 3767/4885RECQL 4352/4885 |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | MEN1 3665/4885KMT2A 3767/4885RECQL 4352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.