Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutathione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 11/20 | 0.57 |
| ▸ | GSTA1 | P08263 | 9/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.57 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.57 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.57 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethacrynic Acid SCHEMBL16507499 | 0.79 | GSTP1 (0.71) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL15288975 | 0.79 | PTGS1 (0.46) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL9717560 | 0.77 | GSTP1 (0.80) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| Glutathione SCHEMBL28002787 | 0.77 | PTGS1 (0.90) | PTGS1GSTK1GLO1 | |
| Glutathione SCHEMBL3395426 | 0.76 | PTGS1 (0.92) | PTGS1GSTK1GLO1 | |
| Ethacrynic Acid SCHEMBL9108011 | 0.76 | GSTP1 (1.00) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| Glutathione SCHEMBL17629816 | 0.75 | PTGS1 (0.90) | PTGS1GSTK1GLO1 | |
| Glutathione SCHEMBL28101166 | 0.75 | PTGS1 (0.90) | PTGS1GSTK1GLO1 | |
| Glutathione SCHEMBL28101167 | 0.75 | PTGS1 (0.90) | PTGS1GSTK1GLO1 | |
| Glutathione SCHEMBL4958127 | 0.75 | PTGS1 (0.90) | PTGS1GSTK1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846746-B2 | Methods of analysis and labeling of protein-protein interactions | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2010-12-07 | — | — | US | disclosed |
| EP-1377828-A4 | METHODS OF ANALYSIS AND LABELING OF PROTEIN-PROTEIN INTERACTIONS | CHILDRENS MEDICAL CENTER (US) | 2006-11-15 | — | — | EP | disclosed |
| US-20050004038-A1 | Bivalent inhibitors of Glutathione-S-Transferases | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-01-06 | — | — | US | disclosed |
| US-20040157279-A1 | Methods of analysis and labeling of protein-protein interactions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-08-12 | — | — | US | disclosed |
| US-6747009-B2 | METABOLICALLY STABLE INHIBITORS OF GLUTATHIONE S-TRANSFERASE; TREATING CANCER | UNIVERSITEIT LEIDEN (NL) | 2004-06-08 | — | — | US | disclosed |
| US-20040063640-A1 | PEPTIDOMIMETIC GLUTATHIONE ANALOGS | UNIVERSITEIT LEIDEN | 2004-04-01 | — | — | US | disclosed |
| EP-1377828-A2 | METHODS OF ANALYSIS AND LABELING OF PROTEIN-PROTEIN INTERACTIONS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002083846-A9 | METHODS OF ANALYSIS AND LABELING OF PROTEIN-PROTEIN INTERACTIONS | CHILDRENS MEDICAL CENTER (US) | 2003-06-19 | — | — | WO | disclosed |
| WO-2002083846-A2 | METHODS OF ANALYSIS AND LABELING OF PROTEIN-PROTEIN INTERACTIONS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2002-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004038-A1 | Bivalent inhibitors of Glutathione-S-Transferases | GSTM1, GSTM2, GSTA2 | GSTP1 5/4885GSTA1 4/4885MEN1 3583/4885 |
| US-20040063640-A1 | PEPTIDOMIMETIC GLUTATHIONE ANALOGS | GSTM1, GSTM2, GSTP1 | GSTP1 3/4885GSTA1 4/4885MEN1 2923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.