Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 2/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3779881 | 0.88 | EGLN1 (0.47) | EGLN1CYP2C9NR4A2 | |
| SCHEMBL3773377 | 0.85 | CYP2C9 (0.64) | EGLN1CYP2C9NR4A2 | |
| SCHEMBL3784622 | 0.84 | NR4A2 (0.45) | EGLN1CYP2C9NR4A2 | |
| SCHEMBL3775806 | 0.82 | NR4A2 (0.51) | EPHB3EGLN1CYP2C9NR4A2IRAK4 | |
| SCHEMBL1733484 | 0.82 | NR4A2 (0.58) | EGLN1CYP2C9NR4A2 | |
| SCHEMBL3778527 | 0.81 | NR4A2 (0.50) | EPHB3EGLN1CYP2C9NR4A2IRAK4 | |
| SCHEMBL3779118 | 0.80 | EGLN1 (0.48) | EGLN1CYP2C9NR4A2 | |
| SCHEMBL3777105 | 0.80 | EPHB3 (0.47) | EPHB3EGLN1CYP2C9NR4A2 | |
| SCHEMBL3773710 | 0.80 | EGLN1 (0.48) | EGLN1CYP2C9NR4A2 | |
| SCHEMBL3367370 | 0.80 | EPHB3 (0.52) | EPHB3EGLN1CYP2C9NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |
| US-8314109-B2 | 6-heterocyclic-imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2012-11-20 | — | — | US | claimed |
| US-20100317675-A1 | 6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-12-16 | — | — | US | claimed |
| US-8691990-B2 | 6-heterocyclic imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2014-04-08 | — | — | US | disclosed |
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | disclosed |
| US-20130041152-A1 | 6-HETEROCYCLIC IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | PEYRONEL JEAN-FRANCOIS (FR) | 2013-02-14 | — | — | US | disclosed |
| US-8314109-B2 | 6-heterocyclic-imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2012-11-20 | — | — | US | disclosed |
| US-20100317675-A1 | 6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130041152-A1 | 6-HETEROCYCLIC IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | XDH, REN, IDH2 | EPHB3 4431/4885EGLN1 1986/4885CYP2C9 209/4885 |
| US-20100317675-A1 | 6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | REN, IDH2, GLS | EPHB3 4453/4885EGLN1 1845/4885CYP2C9 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.