SCHEMBL3770542

SCHEMBL3770542

CCc1ccc(Cc2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)nn(C(C)C)c2C)cc1

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 20/20 0.81
SLC5A1 P13866 17/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2049837 1.00 SLC5A2 (0.81) SLC5A2SLC5A1
SCHEMBL3892693 0.92 SLC5A2 (0.81) SLC5A2SLC5A1
SCHEMBL12757465 0.90 SLC5A2 (0.84) SLC5A2SLC5A1
Remogliflozin SCHEMBL18307653 0.90 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin SCHEMBL18629778 0.90 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin SCHEMBL2378682 0.90 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin SCHEMBL3730054 0.90 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin SCHEMBL17034639 0.90 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin SCHEMBL17127189 0.90 SLC5A2 (1.00) SLC5A2SLC5A1
Remogliflozin SCHEMBL16155105 0.90 SLC5A2 (1.00) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100317575-A1 PHARMACEUTICAL COMPOSITION COMPRISING A PYRAZOLE-O-GLUCOSIDE DERIVATIVE BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-12-16 US claimed
US-20070072813-A1 Methods for preventing and treating metabolic disorders and new pyrazole-O-glycoside derivatives AJINOMOTO CO., INC. (JP) 2007-03-29 US claimed
US-7956041-B2 antidiabetic mixture contains an inhibitor of renal glucose reabsorption and a hypoglycemic agent; controlling blood glucose level; tolbutamide, chlorpropamide, glibenclamide, glipizide, glimepiride, and gliclazide; metformin, phenformin and buformin; repaglinide, nateglinide and mitiglinide AJINOMOTO CO., INC. (JP) 2011-06-07 US disclosed
US-7956041-B2 antidiabetic mixture contains an inhibitor of renal glucose reabsorption and a hypoglycemic agent; controlling blood glucose level; tolbutamide, chlorpropamide, glibenclamide, glipizide, glimepiride, and gliclazide; metformin, phenformin and buformin; repaglinide, nateglinide and mitiglinide AJINOMOTO CO., INC. (JP) 2011-06-07 US disclosed
US-20100317575-A1 PHARMACEUTICAL COMPOSITION COMPRISING A PYRAZOLE-O-GLUCOSIDE DERIVATIVE BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-12-16 US disclosed
US-20100063124-A1 NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM AJINOMOTO CO., INC. (JP) 2010-03-11 US disclosed
US-20100063124-A1 NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM AJINOMOTO CO., INC. (JP) 2010-03-11 US disclosed
US-7645787-B2 Pyrazole derivatives and diabetic medicine containing them AJINOMOTO CO., INC. (JP) 2010-01-12 US disclosed
US-7645787-B2 Pyrazole derivatives and diabetic medicine containing them AJINOMOTO CO., INC. (JP) 2010-01-12 US disclosed
US-20070270479-A1 NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM AJINOMOTO CO. INC (JP) 2007-11-22 US disclosed
US-20070270479-A1 NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM AJINOMOTO CO. INC (JP) 2007-11-22 US disclosed
US-7256209-B2 Pyrazole derivatives and diabetic medicine containing them AJINOMOTO CO., INC. (JP) 2007-08-14 US disclosed
US-7256209-B2 Pyrazole derivatives and diabetic medicine containing them AJINOMOTO CO., INC. (JP) 2007-08-14 US disclosed
US-7247616-B2 Pyrazole derivatives and diabetic medicine containing them AJINOMOTO CO., INC. (JP) 2007-07-24 US disclosed
US-7247616-B2 Pyrazole derivatives and diabetic medicine containing them AJINOMOTO CO., INC. (JP) 2007-07-24 US disclosed
US-20070099979-A1 NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM AJINOMOTO CO. INC (JP) 2007-05-03 US disclosed
US-20070099979-A1 NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM AJINOMOTO CO. INC (JP) 2007-05-03 US disclosed
US-20070072813-A1 Methods for preventing and treating metabolic disorders and new pyrazole-O-glycoside derivatives AJINOMOTO CO., INC. (JP) 2007-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070270479-A1 NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM DPP4, SLC5A2, SLC5A1 SLC5A2 2/4885SLC5A1 3/4885
US-20070072813-A1 Methods for preventing and treating metabolic disorders and new pyrazole-O-glycoside derivatives IAPP, G6PC1, GPR119 SLC5A2 6/4885SLC5A1 4/4885
US-20070099979-A1 NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM DPP4, SLC5A2, SLC5A1 SLC5A2 2/4885SLC5A1 3/4885
US-20100063124-A1 NEW PYRAZOLE DERIVATIVES AND DIABETIC MEDICINE CONTAINING THEM DPP4, SLC5A2, SLC5A1 SLC5A2 2/4885SLC5A1 3/4885
US-20100317575-A1 PHARMACEUTICAL COMPOSITION COMPRISING A PYRAZOLE-O-GLUCOSIDE DERIVATIVE SLC5A1, SLC5A2, G6PC1 SLC5A2 2/4885SLC5A1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.