SCHEMBL377315

SCHEMBL377315

C[C@H](O)C(=O)Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.59
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19167037 0.87 LMNA (0.49) LMNASMN1; SMN2
SCHEMBL7797724 0.84 LMNA (0.60) LMNASMN1; SMN2
SCHEMBL7797725 0.84 LMNA (0.60) LMNASMN1; SMN2
Hydrochloric Acid SCHEMBL377316 0.82 LMNA (0.59) LMNASMN1; SMN2
SCHEMBL28309840 0.82 LMNA (0.63) LMNASMN1; SMN2
SCHEMBL7046446 0.82 LMNA (0.63) LMNASMN1; SMN2
SCHEMBL17343608 0.81 LMNA (0.66) LMNASMN1; SMN2
SCHEMBL5356462 0.79 LMNA (0.40) LMNA
SCHEMBL6879887 0.79 LMNA (0.40) LMNA
SCHEMBL17060668 0.79 LMNA (0.43) LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9096495-B2 Process for the preparation of triiodinated carboxylic aromatic derivatives BRACCO IMAGING S.P.A. (IT) 2015-08-04 US claimed
EP-2408735-B1 PROCESS FOR THE PREPARATION OF TRIIODINATED CARBOXYLIC AROMATIC DERIVATIVES BRACCO IMAGING SPA (IT) 2013-06-05 EP claimed
EP-2408735-A1 PROCESS FOR THE PREPARATION OF TRIIODINATED CARBOXYLIC AROMATIC DERIVATIVES Bracco Imaging S.p.A (IT) 2012-01-25 EP claimed
US-20110275850-A1 Process For The Preparation Of Triiodinated Carboxylic Aromatic Derivatives BRACCO IMAGING S.P.A. (IT) 2011-11-10 US claimed
WO-2010105983-A1 PROCESS FOR THE PREPARATION OF TRIIODINATED CARBOXYLIC AROMATIC DERIVATIVES BRACCO IMAGING SPA (IT) 2010-09-23 WO claimed
EP-2230227-A1 Process for the preparation of triiodinated carboxylic aromatic derivatives Bracco Imaging S.p.A (IT) 2010-09-22 EP claimed
US-9096495-B2 Process for the preparation of triiodinated carboxylic aromatic derivatives BRACCO IMAGING S.P.A. (IT) 2015-08-04 US disclosed
US-9096495-B2 Process for the preparation of triiodinated carboxylic aromatic derivatives BRACCO IMAGING S.P.A. (IT) 2015-08-04 US disclosed
US-9096495-B2 Process for the preparation of triiodinated carboxylic aromatic derivatives BRACCO IMAGING S.P.A. (IT) 2015-08-04 US disclosed
EP-2408735-B1 PROCESS FOR THE PREPARATION OF TRIIODINATED CARBOXYLIC AROMATIC DERIVATIVES BRACCO IMAGING SPA (IT) 2013-06-05 EP disclosed
EP-2408735-B1 PROCESS FOR THE PREPARATION OF TRIIODINATED CARBOXYLIC AROMATIC DERIVATIVES BRACCO IMAGING SPA (IT) 2013-06-05 EP disclosed
EP-2408735-A1 PROCESS FOR THE PREPARATION OF TRIIODINATED CARBOXYLIC AROMATIC DERIVATIVES Bracco Imaging S.p.A (IT) 2012-01-25 EP disclosed
US-20110275850-A1 Process For The Preparation Of Triiodinated Carboxylic Aromatic Derivatives BRACCO IMAGING S.P.A. (IT) 2011-11-10 US disclosed
US-20110275850-A1 Process For The Preparation Of Triiodinated Carboxylic Aromatic Derivatives BRACCO IMAGING S.P.A. (IT) 2011-11-10 US disclosed
US-20110275850-A1 Process For The Preparation Of Triiodinated Carboxylic Aromatic Derivatives BRACCO IMAGING S.P.A. (IT) 2011-11-10 US disclosed
WO-2010105983-A1 PROCESS FOR THE PREPARATION OF TRIIODINATED CARBOXYLIC AROMATIC DERIVATIVES BRACCO IMAGING SPA (IT) 2010-09-23 WO disclosed
WO-2010105983-A1 PROCESS FOR THE PREPARATION OF TRIIODINATED CARBOXYLIC AROMATIC DERIVATIVES BRACCO IMAGING SPA (IT) 2010-09-23 WO disclosed
EP-2230227-A1 Process for the preparation of triiodinated carboxylic aromatic derivatives Bracco Imaging S.p.A (IT) 2010-09-22 EP disclosed
EP-2230227-A1 Process for the preparation of triiodinated carboxylic aromatic derivatives Bracco Imaging S.p.A (IT) 2010-09-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275850-A1 Process For The Preparation Of Triiodinated Carboxylic Aromatic Derivatives PAH, NISCH, TALDO1 LMNA 3046/4885SMN1; SMN2 4765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.