Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3768453 | 0.87 | TSHR (0.58) | TSHRFDPSNOS1HDAC1HDAC6 | |
| SCHEMBL23540099 | 0.82 | TSHR (0.53) | TSHRFDPSNOS1HDAC1HDAC6 | |
| SCHEMBL7147178 | 0.82 | TSHR (0.53) | TSHRFDPSNOS1HDAC1HDAC6 | |
| SCHEMBL16889129 | 0.82 | TSHR (0.53) | TSHRFDPSNOS1HDAC1HDAC6 | |
| SCHEMBL31087987 | 0.79 | — | — | |
| SCHEMBL16885285 | 0.77 | TSHR (0.49) | TSHRFDPSNOS1HDAC1HDAC6 | |
| SCHEMBL9072635 | 0.76 | TSHR (0.47) | TSHRFDPSHDAC1HDAC6JAK2 | |
| SCHEMBL18231656 | 0.75 | — | — | |
| SCHEMBL34468064 | 0.75 | — | — | |
| SCHEMBL11189962 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851570-B2 | Precatalysts useful in polyolefin polymerization reactions | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-12-14 | — | — | US | disclosed |
| US-20080207853-A1 | Precatalysts useful in polyolefin polymerization reactions | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207853-A1 | Precatalysts useful in polyolefin polymerization reactions | PPOX, PORCN, PTGES | TSHR 4793/4885FDPS 64/4885NOS1 1050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.