Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377348 | 1.00 | MAPT (0.55) | MAPTRECQLKDM4ETHRBALOX15 | |
| SCHEMBL6237621 | 0.85 | CYP1A2 (0.47) | SMN1; SMN2CA1CA2CA7CYP1A2 | |
| SCHEMBL7079252 | 0.85 | CYP1A2 (0.47) | SMN1; SMN2CA1CA2CA7CYP1A2 | |
| SCHEMBL918771 | 0.81 | ITGA4 (0.37) | MAPTRECQLKDM4ETHRBALOX15 | |
| SCHEMBL7999598 | 0.80 | KDM4E (0.63) | MAPTRECQLKDM4ETHRBALOX15 | |
| SCHEMBL2298043 | 0.80 | KDM4E (0.63) | MAPTRECQLKDM4ETHRBALOX15 | |
| SCHEMBL112331 | 0.80 | SMN1; SMN2 (0.63) | MAPTRECQLKDM4ETHRBALOX15 | |
| SCHEMBL5599294 | 0.80 | KDM4E (0.63) | MAPTRECQLKDM4ETHRBALOX15 | |
| SCHEMBL7999610 | 0.80 | KDM4E (0.63) | MAPTRECQLKDM4ETHRBALOX15 | |
| SCHEMBL14088106 | 0.80 | SMN1; SMN2 (0.63) | MAPTRECQLKDM4ETHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140357602-A1 | Combination Therapies For Treating Metabolic Disorders | GENMEDICA THERAPEUTICS SL (ES) | 2014-12-04 | — | — | US | disclosed |
| CN-102421424-A | Combination therapies for treating metabolic disorders | ERIC MAYOUX | 2012-04-18 | — | — | CN | disclosed |
| EP-2408441-A1 | COMBINATION THERAPIES FOR TREATING METABOLIC DISORDERS | Genmedica Therapeutics SL (ES) | 2012-01-25 | — | — | EP | disclosed |
| US-20100239552-A1 | Combination Therapies for Treating Metabolic Disorders | GENMEDICA THERAPEUTICS SL (ES) | 2010-09-23 | — | — | US | disclosed |
| WO-2010106083-A1 | COMBINATION THERAPIES FOR TREATING METABOLIC DISORDERS | GENMEDICA THERAPEUTICS SL (ES) | 2010-09-23 | — | — | WO | disclosed |