Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 2/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12536125 | 0.78 | ALDH1A1 (1.00) | ALDH1A1MEN1POLBKMT2ACASP3 | |
| SCHEMBL28593612 | 0.78 | ALDH1A1 (0.41) | ALDH1A1MEN1POLBKMT2ACASP3 | |
| SCHEMBL11200942 | 0.77 | ALDH1A1 (0.65) | ALDH1A1MEN1POLBKMT2ACASP3 | |
| SCHEMBL29785238 | 0.77 | ALDH1A1 (0.65) | ALDH1A1MEN1POLBKMT2ACASP3 | |
| SCHEMBL6318738 | 0.77 | ALDH1A1 (0.50) | ALDH1A1MEN1POLBKMT2ACASP3 | |
| SCHEMBL3772043 | 0.77 | ALDH1A1 (0.65) | ALDH1A1MEN1POLBKMT2ACASP3 | |
| SCHEMBL2816698 | 0.77 | ALDH1A1 (0.65) | ALDH1A1MEN1POLBKMT2ACASP3 | |
| SCHEMBL3778381 | 0.77 | ALDH1A1 (0.65) | ALDH1A1MEN1POLBKMT2ACASP3 | |
| SCHEMBL30291060 | 0.77 | ALDH1A1 (0.65) | ALDH1A1MEN1POLBKMT2ACASP3 | |
| SCHEMBL28026197 | 0.77 | CHRM5 (0.61) | ALDH1A1MEN1KMT2ACHRM5CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384769-B | Synthetic method of R-configuration 3-substituted-3-hydroxy oxindole compound | 陕西师范大学 | 2020-12-22 | — | — | CN | claimed |
| CN-109384769-B | Synthetic method of R-configuration 3-substituted-3-hydroxy oxindole compound | 陕西师范大学 | 2020-12-22 | — | — | CN | disclosed |
| CN-104557957-B | Synthetic method of spiro-oxoindole ethylene oxide derivative | 华东师范大学 | 2017-04-19 | — | — | CN | disclosed |
| US-8552053-B2 | 7-substituted indirubin-3′oximes and their applications | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-10-08 | — | — | US | disclosed |
| US-20100331327-A1 | 7-SUBSTITUTED INDIRUBIN-3'OXIMES AND THEIR APPLICATIONS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2010-12-30 | — | — | US | disclosed |
| EP-1963264-A2 | NEW 3 -, 7-SUBSTITUTED INDIRUBINS AND THEIR APPLICATIONS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007099402-A2 | NEW 3’-, 7-SUBSTITUTED INDIRUBINS AND THEIR APPLICATIONS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-09-07 | — | — | WO | disclosed |
| EP-0750621-B1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1999-07-21 | — | — | EP | disclosed |
| US-5783575-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1998-07-21 | — | — | US | disclosed |
| EP-0750621-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-01-02 | — | — | EP | disclosed |
| US-5536721-A | Thieno[2,3-b-indole derivatives and their use for treating central nervous system diseases related to the metabotropic glutamate receptor system | NOVO NORDISK A/S (DK) | 1996-07-16 | — | — | US | disclosed |
| WO-1995025110-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-09-21 | — | — | WO | disclosed |
| US-4020179-A | ANTICONVULSANTS | RICHARDSON-MERRELL INC. (US) | 1977-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331327-A1 | 7-SUBSTITUTED INDIRUBIN-3'OXIMES AND THEIR APPLICATIONS | UGT2B7, CYP3A7, CYP2E1 | ALDH1A1 310/4885MEN1 3520/4885POLB 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.