Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 5/20 | 0.52 |
| ▸ | CES1 | P23141 | 5/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP4 | P49662 | 1/20 | 0.37 |
| ▸ | CASP9 | P55211 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12536125 | 0.78 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1POLBCASP3 | |
| SCHEMBL11200942 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1POLBCASP3 | |
| SCHEMBL29785238 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1POLBCASP3 | |
| SCHEMBL30291060 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1POLBCASP3 | |
| SCHEMBL3775352 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1POLBCASP3 | |
| SCHEMBL3778381 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1POLBCASP3 | |
| SCHEMBL2816698 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1POLBCASP3 | |
| SCHEMBL9175289 | 0.77 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1POLBCASP3 | |
| SCHEMBL11201120 | 0.74 | KMT2A (0.61) | ALDH1A1KMT2AMEN1POLBCASP3 | |
| SCHEMBL22300696 | 0.73 | MAOA (0.38) | ALDH1A1KMT2AMEN1POLBCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552053-B2 | 7-substituted indirubin-3′oximes and their applications | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-10-08 | — | — | US | disclosed |
| US-20100331327-A1 | 7-SUBSTITUTED INDIRUBIN-3'OXIMES AND THEIR APPLICATIONS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2010-12-30 | — | — | US | disclosed |
| EP-1963264-A2 | NEW 3 -, 7-SUBSTITUTED INDIRUBINS AND THEIR APPLICATIONS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007099402-A2 | NEW 3’-, 7-SUBSTITUTED INDIRUBINS AND THEIR APPLICATIONS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331327-A1 | 7-SUBSTITUTED INDIRUBIN-3'OXIMES AND THEIR APPLICATIONS | UGT2B7, CYP3A7, CYP2E1 | ALDH1A1 310/4885KMT2A 2644/4885MEN1 3520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.