Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL31575663 | 0.95 | LMNA (0.63) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL1052170 | 0.95 | LMNA (0.63) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL3789466 | 0.92 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL3789470 | 0.92 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL3789465 | 0.92 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28408316 | 0.87 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL119824 | 0.87 | LMNA (0.67) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL3788610 | 0.85 | LMNA (0.57) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL6706932 | 0.85 | MEN1 (0.57) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL3458973 | 0.85 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116554576-B | Composite material based on in-situ lignin regeneration and preparation method and application thereof | 山东理工大学 | 2024-04-12 | — | — | CN | claimed |
| CN-116554576-A | Composite material based on in-situ lignin regeneration and preparation method and application thereof | 山东理工大学 | 2023-08-08 | — | — | CN | claimed |
| CN-116554576-B | Composite material based on in-situ lignin regeneration and preparation method and application thereof | 山东理工大学 | 2024-04-12 | — | — | CN | disclosed |
| CN-116554576-B | Composite material based on in-situ lignin regeneration and preparation method and application thereof | 山东理工大学 | 2024-04-12 | — | — | CN | disclosed |
| CN-116554576-A | Composite material based on in-situ lignin regeneration and preparation method and application thereof | 山东理工大学 | 2023-08-08 | — | — | CN | disclosed |
| CN-116554576-A | Composite material based on in-situ lignin regeneration and preparation method and application thereof | 山东理工大学 | 2023-08-08 | — | — | CN | disclosed |
| CN-115160450-B | Rapid preparation method and application of Pholiota nameko polysaccharide | 山西农业大学 | 2023-04-18 | — | — | CN | disclosed |
| CN-115160450-A | Rapid preparation method and application of Pholiota nameko polysaccharide | 山西农业大学 | 2022-10-11 | — | — | CN | disclosed |
| US-8303845-B2 | Porous phosphor, manufacturing method of the porous phosphor, and lighting device coated with the porous phosphor | NATIONAL TSING HUA UNIVERSITY (TW) | 2012-11-06 | — | — | US | disclosed |
| US-20100314992-A1 | Porous phosphor, manufacturing method of the porous phosphor, and lighting device coated with the porous phosphor | NATIONAL TSING HUA UNIVERSITY (TW) | 2010-12-16 | — | — | US | disclosed |