Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | GALR3 | O60755 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL31575663 | 0.90 | LMNA (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1052170 | 0.90 | LMNA (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL316506 | 0.90 | LMNA (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL30113090 | 0.87 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL3345299 | 0.87 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL28408316 | 0.87 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL3789465 | 0.87 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL28990098 | 0.87 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL3789470 | 0.87 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL3789466 | 0.87 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8187489-B1 | Biodegradable ionic liquids for aircraft deicing | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-05-29 | — | — | US | claimed |
| CN-100355737-C | Pyruvic acid type ionic liquid and its preparing method | UNIV EAST CHINA NORMAL (CN) | 2007-12-19 | — | — | CN | claimed |
| CN-1821228-A | Pyruvic acid type ionic liquid and its preparing method | UNIV EAST CHINA NORMAL (CN) | 2006-08-23 | — | — | CN | claimed |
| US-20040006139-A1 | Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof | DEGUSSA AG (DE) | 2004-01-08 | — | — | US | claimed |
| EP-2994161-A1 | PROBIOTIC PREVENTION AND TREATMENT OF COLON CANCER | California Institute of Technology (US) | 2016-03-16 | — | — | EP | disclosed |
| WO-2014182966-A1 | PROBIOTIC PREVENTION AND TREATMENT OF COLON CANCER | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-11-13 | — | — | WO | disclosed |
| US-8187489-B1 | Biodegradable ionic liquids for aircraft deicing | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-05-29 | — | — | US | disclosed |
| CN-100355737-C | Pyruvic acid type ionic liquid and its preparing method | UNIV EAST CHINA NORMAL (CN) | 2007-12-19 | — | — | CN | disclosed |
| CN-1821228-A | Pyruvic acid type ionic liquid and its preparing method | UNIV EAST CHINA NORMAL (CN) | 2006-08-23 | — | — | CN | disclosed |
| US-20040006139-A1 | Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof | DEGUSSA AG (DE) | 2004-01-08 | — | — | US | disclosed |
| US-20040006139-A1 | Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof | DEGUSSA AG (DE) | 2004-01-08 | — | — | US | disclosed |
| US-20040006139-A1 | Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof | DEGUSSA AG (DE) | 2004-01-08 | — | — | US | disclosed |
| EP-1343490-A1 | CHOLINE PYRUVATE, METHOD FOR THE PRODUCTION THEREOF, FORMULATIONS CONTAINING CHOLINE PYRUVATE AND THE USE THEREOF | Degussa AG (DE) | 2003-09-17 | — | — | EP | disclosed |
| EP-1343490-A1 | CHOLINE PYRUVATE, METHOD FOR THE PRODUCTION THEREOF, FORMULATIONS CONTAINING CHOLINE PYRUVATE AND THE USE THEREOF | Degussa AG (DE) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002051398-A1 | CHOLINE PYRUVATE, METHOD FOR THE PRODUCTION THEREOF, FORMULATIONS CONTAINING CHOLINE PYRUVATE AND THE USE THEREOF | DEGUSSA AG (DE) | 2002-07-04 | — | — | WO | disclosed |
| WO-2002051398-A1 | CHOLINE PYRUVATE, METHOD FOR THE PRODUCTION THEREOF, FORMULATIONS CONTAINING CHOLINE PYRUVATE AND THE USE THEREOF | DEGUSSA AG (DE) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006139-A1 | Choline pyruvate, method for the production thereof, formulations containing choline pyruvate and the use thereof | PDK1, PC, PDK4 | MEN1 1006/4885LMNA 1770/4885KMT2A 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.